Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM14951(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluo...)
Affinity DataIC50: <1nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM14951(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluo...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck [245-498](Homo sapiens (Human))
Amgen

LigandPNGBDBM14951(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluo...)
Affinity DataIC50:  19nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed