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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Amgen
Ligand
BDBM14951
(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluo...)
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Affinity Data
IC50: <1nM
Assay Description:
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Angiopoietin-1 receptor
(Homo sapiens (Human))
Amgen
Ligand
BDBM14951
(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluo...)
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Copy InChI
Affinity Data
IC50: 11nM
pH: 7.5 T: 2°C
Assay Description:
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein kinase Lck [245-498]
(Homo sapiens (Human))
Amgen
Ligand
BDBM14951
(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 19nM
Assay Description:
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI