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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
13
hits in this display
Target
Dual specificity protein kinase CLK1
(Homo sapiens (Human))
Clermont Universite£
Curated by
ChEMBL
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 220nM
Assay Description:
Inhibition of human recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate
More data for this Ligand-Target Pair
Target Info
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT)
Clermont Universite£
Curated by
ChEMBL
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 330nM
Assay Description:
Inhibition of rat recombinant GST-tagged DYRK1A using myelin protein as substrate and [gamma32]-ATP after 30 mins by scintillation counting
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Target
cGMP-dependent protein kinase 1
(Bos taurus (bovine))
Cnrs
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 400nM
T: 2°C
Assay Description:
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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Target
cAMP-dependent protein kinase catalytic subunit alpha
(Bos taurus (bovine))
Cnrs
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 700nM
T: 2°C
Assay Description:
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...
More data for this Ligand-Target Pair
Target Info
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Target
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human))
Keimyung University
Curated by
ChEMBL
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of PIM1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human))
Keimyung University
Curated by
ChEMBL
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 1.04E+3nM
Assay Description:
Inhibition of PIM1 kinase (unknown origin) using 5-FAM-labeled BAD peptide as substrate after 90 mins by fluorescence polarization assay
More data for this Ligand-Target Pair
Target Info
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Target
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human))
Clermont Universite£
Curated by
ChEMBL
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 1.20E+3nM
Assay Description:
Inhibition of human recombinant CDK5/p25 using Histone H1 and [gamma32]-ATP after 30 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Glycogen synthase kinase-3 beta
(Rattus norvegicus (rat))
Cnrs
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 2.00E+3nM
T: 2°C
Assay Description:
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Sterling Road
Curated by
ChEMBL
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of human GSK3beta
More data for this Ligand-Target Pair
Target Info
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MMDB
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Target
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human))
Cnrs
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 3.00E+3nM
pH: 7.2 T: 2°C
Assay Description:
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Cyclin-dependent kinase 5 activator 1 [99-307]
(Homo sapiens (Human))
Cnrs
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 6.00E+3nM
pH: 7.2 T: 2°C
Assay Description:
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Target
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 1.20E+4nM
Assay Description:
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
DrugBank
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Target
Casein kinase I isoform alpha
(Rattus norvegicus (rat))
Cnrs
Ligand
BDBM10840
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
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Affinity Data
IC50: 3.00E+4nM
T: 2°C
Assay Description:
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI