Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50376356(CHEMBL429516)Copy SMILESCopy InChI

Affinity DataIC50:  5nMAssay Description:Inhibition of KDR in presence of 1 mM ATPMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50376356(CHEMBL429516)Copy SMILESCopy InChI

Affinity DataIC50:  7nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50376356(CHEMBL429516)Copy SMILESCopy InChI

Affinity DataIC50:  22nMAssay Description:Inhibition of cKitMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetVascular endothelial growth factor receptor 2(Mus musculus)
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50376356(CHEMBL429516)Copy SMILESCopy InChI

Affinity DataIC50:  345nMAssay Description:Inhibition of VEGF-induced KDR phosphorylation in mouse 3T3 cellsMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI