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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

LigandPNGBDBM27439(8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca...)
Affinity DataKi:  1.20E+3nM ΔG°:  -35.2kJ/mole IC50:  1.20E+4nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM27439(8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca...)
Affinity DataIC50:  680nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma32P]ATP after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27439(8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of rat recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate and [gamma32P]ATP after 30 mins by sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
The Walter And Eliza Hall Institute Of Medical Research

Curated by ChEMBL
LigandPNGBDBM27439(8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of LIMK1 using cofilin-2 as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM27439(8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged CDK5/p25 expressed in Escherichia coli using histone H1 as substrate and [gamma32P]ATP after 30 mins by sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed