Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 6 hits in this display
BDBM154597(US8999957, Column 152, Compound 2 | US8999957, Tab...)
BDBM154597(US8999957, Column 152, Compound 2 | US8999957, Tab...)
IC50: 304nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
BDBM154597(US8999957, Column 152, Compound 2 | US8999957, Tab...)
BDBM154597(US8999957, Column 152, Compound 2 | US8999957, Tab...)
IC50: 485nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
BDBM154597(US8999957, Column 152, Compound 2 | US8999957, Tab...)
BDBM154597(US8999957, Column 152, Compound 2 | US8999957, Tab...)
Kd: 118nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair