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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50377058
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of FMS
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
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Ligand Info
CHEMBL
MMDB
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PC sid
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Article
PubMed
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Target
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50377058
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
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Affinity Data
IC50: 1.10nM
Assay Description:
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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MMDB
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Article
PubMed
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Target
Macrophage colony-stimulating factor 1 receptor
(Mus musculus (Mouse))
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50377058
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
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Affinity Data
IC50: 7.20nM
Assay Description:
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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MMDB
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Article
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Target
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Ligand
BDBM50377058
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
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Affinity Data
IC50: 71nM
Assay Description:
The compounds of the present invention are also specific inhibitors of c-Kit. Selection of preferred compounds of Formula I for use as c-Kit inhibito...
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Target Info
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US Patent
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50377058
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
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Affinity Data
IC50: 4.10E+3nM
Assay Description:
Inhibition of CYP2C9
More data for this Ligand-Target Pair
Target Info
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MMDB
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Article
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50377058
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Displacement of [3H]astemizole from human ERG potassium channel
More data for this Ligand-Target Pair
Target Info
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KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
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Article
PubMed
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50377058
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP3A4
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
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Article
PubMed
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50377058
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP1A2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
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MMDB
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Article
PubMed
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Target
Cytochrome P450 2C19
(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50377058
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP2C19
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI