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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 15 hits in this display   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  52nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 3 [VEGFR-3(Flt-4)] expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  99nMAssay Description:In vitro inhibition of Colony stimulating factor 1 receptor (CSF-1R) expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  105nMAssay Description:In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 1 (VEGFR-1) expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  357nMAssay Description:In vitro inhibition of Platelet-derived growth factor receptor beta expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  5.10E+3nMAssay Description:In vitro inhibition of Fibroblast growth factor receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  5.33E+3nMAssay Description:In vitro inhibition of c-Abl tyrosine kinase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  6.80E+3nMAssay Description:In vitro inhibition of Tyrosine protein kinase receptor TIE-2 (Tek) expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibition of Epidermal growth factor receptor (HER-1,ErbB) expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibition of c-SRC kinase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibition of Met proto-oncogene tyrosine kinase (c-Met) expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibition of Cyclin-dependent kinase 1 (CDK-1) expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
Affinity DataIC50:  6.40E+4nMAssay Description:In vitro inhibition of Insulin-like growth factor I receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed