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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
hits in this display
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 1.20nM
Assay Description:
Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 9nM
Assay Description:
In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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PC sid
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Article
PubMed
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Target
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 52nM
Assay Description:
In vitro inhibition of Vascular endothelial growth factor receptor 3 [VEGFR-3(Flt-4)] expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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Article
PubMed
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Target
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 99nM
Assay Description:
In vitro inhibition of Colony stimulating factor 1 receptor (CSF-1R) expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
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Article
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Target
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 105nM
Assay Description:
In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
antibodypedia
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Ligand Info
CHEMBL
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In Depth
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Article
PubMed
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Target
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 130nM
Assay Description:
In vitro inhibition of Vascular endothelial growth factor receptor 1 (VEGFR-1) expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
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Article
PubMed
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Target
Platelet-derived growth factor receptor beta
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 357nM
Assay Description:
In vitro inhibition of Platelet-derived growth factor receptor beta expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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PubMed
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Target
Fibroblast growth factor receptor 1
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 5.10E+3nM
Assay Description:
In vitro inhibition of Fibroblast growth factor receptor expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Article
PubMed
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Target
Tyrosine-protein kinase ABL1
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 5.33E+3nM
Assay Description:
In vitro inhibition of c-Abl tyrosine kinase expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Article
PubMed
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Target
Angiopoietin-1 receptor
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 6.80E+3nM
Assay Description:
In vitro inhibition of Tyrosine protein kinase receptor TIE-2 (Tek) expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
In vitro inhibition of Epidermal growth factor receptor (HER-1,ErbB) expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
In vitro inhibition of c-SRC kinase expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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In Depth
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Article
PubMed
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Target
Macrophage-stimulating protein receptor
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
In vitro inhibition of Met proto-oncogene tyrosine kinase (c-Met) expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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antibodypedia
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In Depth
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Article
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Target
Cyclin-dependent kinase 1
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
In vitro inhibition of Cyclin-dependent kinase 1 (CDK-1) expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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antibodypedia
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In Depth
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Target
Insulin-like growth factor 1 receptor
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM50121980
(CHEMBL347537 | N-(3-Isoquinolin-4-yl-phenyl)-2-[(p...)
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Affinity Data
IC50: 6.40E+4nM
Assay Description:
In vitro inhibition of Insulin-like growth factor I receptor expressed in baculovirus
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI