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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
89
hits in this display
Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 0.5nM
Assay Description:
Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]OXO-M radioligand (in vitro)
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.5nM
Assay Description:
Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.5nM
Assay Description:
Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.5nM
Assay Description:
In vitro ability to displace 3H-cis-methyltrimethylammoniummethyl-1,3-dioxolane [3H]CD) from rat cortical Muscarinic acetylcholine receptor in compet...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.5nM
Assay Description:
Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.10nM
Assay Description:
Binding affinity to human cloned muscarinic M1 receptor expressed in CHO cells
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.10nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.5nM
Assay Description:
Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M4 in CHO cell membranes
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(Mus musculus)
University Of South Carolina
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 1.70nM
Assay Description:
Ability of the compound to displace [3H]-oxotremorine ([3H]-OXO-M) from mouse cerebral cortex
More data for this Ligand-Target Pair
Target Info
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Target
Acetylcholinesterase
(Mus musculus (mouse))
University Of South Carolina
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 1.70nM
Assay Description:
Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue.
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4nM
Assay Description:
Binding activity to muscarinic acetylcholine receptor in rat heart, assayed using [3H]-QNB as a radioligand.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 17nM
Assay Description:
Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M1 expressed in CHO cell membranes
More data for this Ligand-Target Pair
Target Info
Reactome pathway
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 60nM
Assay Description:
Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 60nM
Assay Description:
Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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PubMed
Copy BDB DOI
Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 60nM
Assay Description:
In vitro ability to displace [3H]quinuclidinyl benzilate [3H]QNB) from rat cortical Muscarinic acetylcholine receptor in competition assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 84nM
Assay Description:
Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M1
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 120nM
Assay Description:
Binding affinity at [3H]PZ radiolabeled muscarinic M1 receptor in rat cortex.
More data for this Ligand-Target Pair
Target Info
Reactome pathway
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 140nM
Assay Description:
Binding activity to muscarinic acetylcholine receptor in rat heart, assayed using [3H]QNB as a radioligand in the presence of Gpp(NH)p.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
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CHEMBL
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PubMed
Copy BDB DOI
Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 140nM
Assay Description:
Binding activity to the muscarinic acetylcholine receptor in rat cortex, assayed using [3H]PZ as a radioligand.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
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Affinity Data
Ki: 148nM
Assay Description:
Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting ...
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 160nM
Assay Description:
Inhibition of [3H]- quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M4 expressed in CHO cell membranes
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 160nM
Assay Description:
Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 193nM
Assay Description:
Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]QNB radioligand (in vitro)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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PubMed
Copy BDB DOI
Target
Muscarinic acetylcholine receptor M1
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 196nM
Assay Description:
Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor in rat cortex
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 199nM
Assay Description:
Binding affinity to Muscarinic acetylcholine receptor M2 by measuring its ability to displace [3H]N-methylscopolamine binding in rat heart
More data for this Ligand-Target Pair
Target Info
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Target
Beta-arrestin-1
(RABBIT)
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
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Affinity Data
Ki: 214nM
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 230nM
Assay Description:
Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assay
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 235nM
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 290nM
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 324nM
Assay Description:
Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M3
(RAT)
National University Of Singapore
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 398nM
Assay Description:
Binding affinity to Muscarinic acetylcholine receptor M3 by measuring its ability to displace [3H]N-methylscopolamine binding in rat submandibulary g...
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 480nM
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 490nM
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 500nM
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 630nM
Assay Description:
Binding affinity to Muscarinic acetylcholine receptor M1 by measuring its ability to displace [3H]pirenzepine from rat cerebral cortex
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Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 660nM
Assay Description:
Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 660nM
Assay Description:
Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 830nM
Assay Description:
In vitro inhibition of binding of (-)-[3H]-NMS to Muscarinic acetylcholine receptor of rat cerebral cortex was determined
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 851nM
Assay Description:
Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)pipe...
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 1.02E+3nM
Assay Description:
Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)p...
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Target
Muscarinic acetylcholine receptor M2
(Mus musculus)
University Of South Carolina
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 1.50E+3nM
Assay Description:
Ability of the compound to displace [3H]-methylscopolamine ([3H]-NMS) from mouse cerebral cortex
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Target
Acetylcholinesterase
(Mus musculus (mouse))
University Of South Carolina
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 1.50E+3nM
Assay Description:
Compound was evaluated for the binding affinity by displacing [3H]methylscopolamine [3H]NMS from mouse cerebral cortex tissue.
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Target
Beta-arrestin-1
(RABBIT)
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 1.56E+3nM
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 1.78E+3nM
Assay Description:
Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4...
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 1.00E+4nM
Assay Description:
Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation c...
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 1.00E+4nM
Assay Description:
Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Muscarinic acetylcholine receptor DM1
(Drosophila melanogaster)
University Of California
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 1.94E+4nM
Assay Description:
Displacement of [3H]QNB from Drosophila melanogaster mAChR by scintillation counting
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Target
Muscarinic acetylcholine receptor DM1
(Drosophila melanogaster)
University Of California
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Ki: 2.15E+4nM
Assay Description:
Displacement of [3H]AF-DX 384 from Drosophila melanogaster mAChR by scintillation counting
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 1.5nM
Assay Description:
Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptor
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 2nM
Assay Description:
Binding affinity against Muscarinic receptor M2 in rat brain using [3H]-QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 2.30nM
Assay Description:
Ability to displace [3H]-oxotremorine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 2.80nM
Assay Description:
Ability to displace [3H]cis--2-methyl-5-((dimethylamino)methyl)-1,3-di oxolane from muscarinic acetylcholine receptor in rat cortical tissue.
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 17nM
Assay Description:
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 17nM
Assay Description:
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 84nM
Assay Description:
Muscarinic receptor M2 in rat heart using [3H]-QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a co...
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 100nM
Assay Description:
Binding affinity against Muscarinic receptor M1 in rat brain using [3H]-PZ (pirenzepine) radioligand at a concentration of 1 nM
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 113nM
Assay Description:
Ability to displace [3H]-pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 360nM
Assay Description:
Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 recept...
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 364nM
Assay Description:
Displacement of [3H]-QNB in genetically transformed mouse cell line (m1C2) transfected with Muscarinic acetylcholine receptor M1
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 400nM
Assay Description:
Compound was evaluated for its ability to displace [3H]- N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetyl...
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 407nM
Assay Description:
Inhibition of 0.03 nM [3H]quinuclidinyl benzylate binding to rat neocortex muscarinic receptor
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 660nM
Assay Description:
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 858nM
Assay Description:
Displacement of [3H]-QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 860nM
Assay Description:
Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Medical Research Division Of American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Binding affinity against Muscarinic receptor M2 in rat brain using [3H]-QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 2.70E+3nM
Assay Description:
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic acetylcholine receptor
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Upjohn
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Compound was evaluated for its ability to displace [3H]- N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetyl...
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
Novo Nordisk
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 8.00E+3nM
Assay Description:
Compound was evaluated for its ability to displace [3H]- N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetyl...
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 9.00E+3nM
Assay Description:
Compound was evaluated for its ability to displace [3H]-N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetylc...
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Novo Nordisk
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 1.70E+4nM
Assay Description:
Compound was evaluated for its ability to displace [3H]-N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetylc...
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
IC50: 2.71E+4nM
Assay Description:
Ability to displace [3H]-N-methylscopolamine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 14nM
Assay Description:
Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...
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Target
Muscarinic acetylcholine receptor
(Cavia porcellus)
University Of Uppsala
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 50nM
Assay Description:
Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assay
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Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Homo sapiens (Human))
University Of Uppsala
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Kd: 930nM
Assay Description:
Dissociation constant of the drug-Muscarinic acetylcholine receptor complex.
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 1.60nM
Assay Description:
Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
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Target
Muscarinic acetylcholine receptor M1
(Mus musculus)
The University Of Toledo
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 270nM
Assay Description:
Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 390nM
Assay Description:
In Vitro evaluation of the compound activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplificat...
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Novo Nordisk
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 210nM
Assay Description:
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 33nM
Assay Description:
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M4 determined by receptor selection and amplification technology (R-SAT)
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
Novo Nordisk
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 55nM
Assay Description:
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 19nM
Assay Description:
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
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Target
Muscarinic acetylcholine receptor
(Cavia porcellus)
University Of Uppsala
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
Kd: 1.20E+3nM
Assay Description:
Dissociation constant for complex with muscarinic acetylcholine receptor M3 of guinea pig ileum
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 9nM
Assay Description:
Positive allosteric modulatory activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assess...
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Target
Mucolipin-3
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: >2.99E+4nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...
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Ion channel NompC
(Danio rerio)
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM50004665
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
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Affinity Data
EC50: 2.99E+4nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...
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