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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 17 hits in this display   

TargetMu-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  84nMAssay Description:Binding affinity against mu opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  84nMAssay Description:Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  101nMAssay Description:Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  101nMAssay Description:Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  149nMAssay Description:Inhibition of human dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  496nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  538nMAssay Description:Inhibition of human dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  552nMAssay Description:Binding affinity against L-type calcium channel verapamil siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  1.84E+3nMAssay Description:Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of ligand binding to human delta opioid receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  2.25E+3nMAssay Description:Binding affinity against dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  2.42E+3nMAssay Description:Inhibition of human ORL1 orphanin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  2.81E+3nMAssay Description:Binding affinity against norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  2.83E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  3.59E+3nMAssay Description:Binding affinity against beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105076(8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4...)
Affinity DataIC50:  4.54E+3nMAssay Description:Binding affinity against muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed