Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetThymidylate synthase(Homo sapiens (Human))
Universit£

Curated by ChEMBL

LigandBDBM50146058(Benzo[de]isochromene-1,3-dione | CHEMBL316059)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of human thymidylate synthase AMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLKEGGPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetThymidylate synthase(Escherichia coli)
Universit£

Curated by ChEMBL

LigandBDBM50146058(Benzo[de]isochromene-1,3-dione | CHEMBL316059)Copy SMILESCopy InChI

Affinity DataKi: >2.94E+5nMAssay Description:Inhibition of Escherichia coli thymidylate synthase AMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPurchaseCHEMBLKEGGPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL

LigandBDBM50146058(Benzo[de]isochromene-1,3-dione | CHEMBL316059)Copy SMILESCopy InChI

Affinity DataIC50:  8.80E+3nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseCHEMBLKEGGPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI