Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50391762(CHEMBL2146870)Copy SMILESCopy InChI

Affinity DataIC50:  26nMAssay Description:Inhibition of ROMK by electrophysiology assayMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50391762(CHEMBL2146870)Copy SMILESCopy InChI

Affinity DataIC50:  89nMAssay Description:Inhibition of ROMK (unknown origin) after 30 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50391762(CHEMBL2146870)Copy SMILESCopy InChI

Affinity DataIC50:  89nMAssay Description:Inhibition of ROMK (unknown origin) after 30 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50391762(CHEMBL2146870)Copy SMILESCopy InChI

Affinity DataIC50:  89nMAssay Description:Inhibition of human ROMK1 channel expressed in CHO cells coexpressing DHFR assessed as inhibition of 86Rb+ efflux after 35 mins by TopCount methodMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL

LigandBDBM50391762(CHEMBL2146870)Copy SMILESCopy InChI

Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL

LigandBDBM50391762(CHEMBL2146870)Copy SMILESCopy InChI

Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of [35S]MK499 from human ERGMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL

LigandBDBM50391762(CHEMBL2146870)Copy SMILESCopy InChI

Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI