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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
28
hits in this display
Target
Heat shock protein HSP 90-alpha
(Homo sapiens (Human))
Emory University
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 280nM
pH: 7.4 T: 2°C
Assay Description:
A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...
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Target
Ephrin type-B receptor 4
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 800nM
Assay Description:
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...
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Target
Dual specificity protein phosphatase 6
(Rattus norvegicus)
Sanford-Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 1.19E+3nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
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Target
Beta-lactamase
(Pseudomonas aeruginosa)
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 1.72E+3nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...
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Target
Beta-lactamase
(Salmonella enterica subsp. enterica serovar Choler...)
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 3.02E+3nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...
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Target
Voltage-dependent N-type calcium channel subunit alpha-1B
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 3.18E+3nM
Assay Description:
Data Source: Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute Network...
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Target
Beta-lactamase
(Pseudomonas aeruginosa)
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 5.39E+3nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...
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Target
Dual specificity protein phosphatase 6
(Rattus norvegicus)
Sanford-Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 2.02E+4nM
Assay Description:
The in vitro MKP-3 Phosphatase dose response hit/probe assessment assay has been developed and run at the University of Pittsburgh Molecular Screenin...
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Target
Mitogen-activated protein kinase 10
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 2.22E+4nM
Assay Description:
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...
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Target
Dual specificity protein phosphatase 1
(Homo sapiens (Human))
University Of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 2.77E+4nM
Assay Description:
The MKP-1 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-1 inhibit...
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Target Info
PDB
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Target
Dual specificity protein phosphatase 1
(Homo sapiens (Human))
University Of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 2.78E+4nM
pH: 7.0 T: 2°C
Assay Description:
The MKP-1 HTS confirmation dose response assay has been developed to confirm actives identified in the MH-76391 In vitro HTS assay for MKP-1 inhibito...
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Target Info
PDB
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Target
Heat shock protein HSP 90-alpha
(Homo sapiens (Human))
Emory University
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: >3.00E+4nM
Assay Description:
Emory Chemistry-Biology Discovery Center Assay Overview: MLSCN Grant: 1 X01MH78953-01 Hsp90 is a chaperon with important roles in maintaining transfo...
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Target Info
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Target
Dual specificity protein phosphatase 1
(Homo sapiens (Human))
University Of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 3.52E+4nM
Assay Description:
The MKP-1 dose response Active/Probe assessment-DTT assay has been developed to evaluate the effects of increased DTT concentration on the MKP-1 inhi...
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Target
Dual specificity protein phosphatase 1
(Homo sapiens (Human))
University Of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 3.52E+4nM
Assay Description:
The MKP-1 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-1...
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Target Info
PDB
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Target
Dual specificity protein phosphatase 6
(Rattus norvegicus)
Sanford-Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: 4.76E+4nM
Assay Description:
The MKP-3 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-3...
More data for this Ligand-Target Pair
Target Info
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Target
Dual specificity protein phosphatase 6
(Rattus norvegicus)
Sanford-Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
Copy SMILES
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
The MKP-3 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-3 inhibit...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Bcl-2-related protein A1
(Mus musculus (Mouse))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: >1.00E+5nM
pH: 7.0 T: 2°C
Assay Description:
The aim is to identify chemical probes of Bfl-1 through a fluorescence polarization assay (FPA) using FITC-Bid BH3 peptide. 1) Dose-response curves c...
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Target
Bcl-2-related protein A1
(Mus musculus (Mouse))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Broad Institute
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
EC50: 1.67E+5nM
Assay Description:
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...
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Target
Serine/threonine-protein kinase 33
(Homo sapiens (Human))
Broad Institute
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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EC50: 8.03E+3nM
Assay Description:
Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...
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Target
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
EC50: 3.00E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: 1R03MH084830-01 Project Title: TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain...
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Target
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
EC50: 3.00E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: 1R03MH084830-01 Project Title: TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain...
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MMDB
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels And Transporters
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
EC50: 0.00572nM
Assay Description:
Assay Provider: Val Watts Assay Provider Affiliation: Purdue University Grant Title: Allosteric Modulators of D1 Receptors Grant Number: 1 X01 MH0776...
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Target
Apoptosis regulator Bcl-2
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
EC50: 4.05E+3nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...
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Target
Bcl-2-like protein 2
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
EC50: 1.11E+3nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...
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Target
Glutathione S-transferase Mu 1
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
EC50: 1.72E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...
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Target Info
PDB
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Target
Protein LANA1
(Human herpesvirus 8)
Broad Institute
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
EC50: 549nM
Assay Description:
Primary Collaborators: Kenneth Kaye,Brigham & Womens,Boston MA,kkaye@rics.bwh.harvard.edu,617-525-4256 Chantal Beauchemin,Brigham & Womens,Boston MA,...
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Target
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32050
(MLS000080844 | SMR000044769 | cid_663844)
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Affinity Data
EC50: 1.14E+3nM
pH: 7.4 T: 2°C
Assay Description:
The HTS assay was conducted in 384-well microplates in a total assay volume per well of 10.1 microliters (5 microliters of bead mixture, 0.1 microlit...
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