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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 27 hits in this display   

TargetInosine-5'-monophosphate dehydrogenase(Cryptococcus neoformans var. neoformans serotype D...)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  370nMAssay Description:Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1E(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  1.04E+3nMpH: 7.4 T: 2°CAssay Description:To measure 5-HT1E activity, a Chinese Hamster Ovary (CHO) cell line was developed at the Scripps Molecular Research Institute Screening center. This ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of recombinant human His-tagged IMPDH2 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  2.33E+3nMAssay Description:External Assay ID: S1P3_IC50_CS_5H1E_Antagonists Name: S1P3 Dose Response Assay Counterscreen for 5-Hydroxytryptamine(Serotonin) Receptor Subtype 1E ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  2.48E+3nMpH: 7.4 T: 2°CAssay Description:A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetIsoform 2 of Nuclear receptor ROR-alpha (Alpha-2)(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  3.37E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
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TargetSteroidogenic factor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  3.90E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDNA damage-inducible transcript 3 protein(Mus musculus)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  4.10E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
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TargetDNA damage-inducible transcript 3 protein(Mus musculus)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  4.10E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHistone acetyltransferase GCN5(Saccharomyces cerevisiae S288c)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetX-box-binding protein 1(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  5.04E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetIsoform 2 of Nuclear receptor ROR-alpha (Alpha-2)(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  5.14E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
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TargetTumor necrosis factor(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  5.52E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetLanosterol synthase(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of recombinant human His-tagged IMPDH1 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroidogenic factor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  6.04E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
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TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  6.09E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, C...More data for this Ligand-Target Pair
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TargetHistone acetyltransferase GCN5(Saccharomyces cerevisiae S288c)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNucleotide-binding oligomerization domain-containing protein 2(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  6.48E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetApelin receptor(Homo sapiens (Human))
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  1.02E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford- Sanford-Burnham Medical Research Institute(SBMRI, San...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase GCN5(Saccharomyces cerevisiae S288c)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase GCN5(Saccharomyces cerevisiae S288c)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNucleotide-binding oligomerization domain-containing protein 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataEC50:  2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataEC50:  2.06E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataEC50:  3.16E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataEC50:  2.35E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetBcl-2-like protein 11(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM31072(2-[(1,1-dioxido-1-benzothien-3-yl)thio]-5-phenyl-1...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
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