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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
Sunchon National University
Curated by
ChEMBL
Ligand
BDBM50331545
(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
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Affinity Data
Ki: 460nM
Assay Description:
Competitive inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by L...
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Target Info
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Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
Sunchon National University
Curated by
ChEMBL
Ligand
BDBM50331545
(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
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Affinity Data
IC50: 880nM
Assay Description:
Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by spectrophotom...
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
antibodypedia
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ChEBI
CHEMBL
MCE
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Article
PubMed
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Target
Nuclear factor NF-kappa-B p105 subunit
(Homo sapiens (Human))
Biopharmanet
Curated by
ChEMBL
Ligand
BDBM50331545
(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
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Affinity Data
IC50: 2.50E+3nM
Assay Description:
Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSA
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Target Info
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Sunchon National University
Curated by
ChEMBL
Ligand
BDBM50331545
(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
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Affinity Data
IC50: 2.73E+3nM
Assay Description:
Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophoto...
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Target
Amine oxidase [flavin-containing] A
(Rattus norvegicus (rat))
Sunchon National University
Curated by
ChEMBL
Ligand
BDBM50331545
(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
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Affinity Data
IC50: 9.00E+3nM
Assay Description:
Inhibition of MAO-A in Sprague-Dawley rat brain mitochondrial fraction after 10 mins in presence of [14C]5-hydroxytryptamine by liquid scintillation ...
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Target Info
PDB
MMDB
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Target
Acetylcholinesterase
(Electrophorus electricus (Electric eel))
Sunchon National University
Curated by
ChEMBL
Ligand
BDBM50331545
(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
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Affinity Data
IC50: 2.54E+4nM
Assay Description:
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...
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Target
Replicase polyprotein 1a
(Human SARS coronavirus (SARS-CoV))
Gyeongsang National University
Ligand
BDBM50331545
(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
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Affinity Data
IC50: >1.50E+5nM
pH: 8.0
Assay Description:
Reactions were performed in a total volume of 200 mL, which contained thefollowing components: 20mM Tris-buffer, pH 8.0, 10mM DTT, 30 mM Z-RLRGG-AMC,...
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Target Info
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Target
Beta-secretase 1
(Homo sapiens (Human))
Kinki University
Curated by
ChEMBL
Ligand
BDBM50331545
(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
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Affinity Data
IC50: >5.00E+5nM
Assay Description:
Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins by fluorescence quenching assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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ChEBI
CHEMBL
MCE
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PC sid
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In Depth
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Article
PubMed
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