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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50331545(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
Affinity DataKi:  460nMAssay Description:Competitive inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50331545(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
Affinity DataIC50:  880nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by spectrophotom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50331545(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50331545(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
Affinity DataIC50:  2.73E+3nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophoto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50331545(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of MAO-A in Sprague-Dawley rat brain mitochondrial fraction after 10 mins in presence of [14C]5-hydroxytryptamine by liquid scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50331545(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
Affinity DataIC50:  2.54E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1a(Human SARS coronavirus (SARS-CoV))
Gyeongsang National University

LigandPNGBDBM50331545(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
Affinity DataIC50: >1.50E+5nMpH: 8.0Assay Description:Reactions were performed in a total volume of 200 mL, which contained thefollowing components: 20mM Tris-buffer, pH 8.0, 10mM DTT, 30 mM Z-RLRGG-AMC,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Kinki University

Curated by ChEMBL
LigandPNGBDBM50331545(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins by fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed