Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 26 hits in this display   

TargetAdenosine receptor A1(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]R-PIA from rat forebrain adenosine receptor-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Mus musculus)
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  47.9nMAssay Description:Displacement of [3H]R-PIA from human A1 adenosine receptor expressed in CHO cells after 60 min by Perkin Elmer Liquid Scintillation AnalyzerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  47.9nMAssay Description:Displacement of [3H]R-PIA from human recombinant adenosine receptor-1 expressed in CHO cell membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]N6-phenylisopropyladenosine from recombinant human A1AR expressed in CHO cell membranes after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  470nMAssay Description:Displacement of [125I]AB-MECA from human recombinant adenosine receptor-3 expressed in CHO cell membrane after 60 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  470nMAssay Description:Displacement of [125I]I-AB-MECA from human A3 adenosine receptor expressed in CHO cells after 60 min Packard Cobra 2 gamma-counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  470nMAssay Description:Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5-N-methyluronamide from human A3A adenosine receptor expressed in CHO cell membranes after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane domain-containing protein TMIGD3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  470nMAssay Description:Displacement of [125l]N 6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from recombinant human A3AR expressed in CHO cell membranes after 60 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  641nMAssay Description:Inhibition of 5HT2B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  675nMAssay Description:Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Mus musculus)
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  1.06E+3nMAssay Description:Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5-N-methyluronamide from mouse A3A adenosine receptor expressed in CHO cell membranes after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  1.85E+3nMAssay Description:Inhibition of 5HT2C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  1.86E+3nMAssay Description:Displacement of [3H]mesulergine from human 5-HT2CR expressed in Flp-In HEK cell membranes incubated for 90 mins under dark condition by microbeta sci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  3.95E+3nMAssay Description:Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-5-N-ethylcarboxamidoadenosine from human A2A adenosine receptor expressed in HEK293 cell m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  3.95E+3nMAssay Description:Displacement of [3 H]2-[p-(2-carboxyethyl)phenyl-ethylamino]-5'-N-ethylcarboxamidoadenosine from recombinant human adenosine receptor A2A expressed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  3.95E+3nMAssay Description:Displacement of [3H]CGS21680 from human A2a adenosine receptor expressed in HEK293 cells after 60 min by Perkin Elmer Liquid Scintillation AnalyzerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi:  3.95E+3nMAssay Description:Displacement of [3H]CGS21680 from human recombinant adenosine receptor-2A expressed in HEK293 cell membrane after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK-T cell membranes incubated for 90 mins under dark condition by microbeta s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP2D6 using dextromethorphan as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP2C9 using tolbutamide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataEC50:  6.70nMAssay Description:Agonist activity at rat A1A adenosine receptor expressed in CHO-K1 cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataEC50:  1.37E+3nMAssay Description:Agonist activity at human A3A adenosine receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50379107(CHEMBL2012686)
Affinity DataEC50:  40.7nMAssay Description:Agonist activity at human recombinant adenosine receptor-1 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed