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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM203548
(US9221809, 105)
Copy SMILES
Affinity Data
IC50: 85nM
pH: 7.2 T: 2°C
Assay Description:
A 20 ul reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (RP7030, Molecul...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM203548
(US9221809, 105)
Copy SMILES
Affinity Data
IC50: 85nM
Assay Description:
Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM203548
(US9221809, 105)
Copy SMILES
Affinity Data
IC50: 333nM
Assay Description:
Inhibition of IRAK4-mediated NFkappaB activation in human THP1-XBlue cells assessed as LPS-induced secreted embryonic alkaline phosphatase activity t...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI