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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by
ChEMBL
Ligand
BDBM50250808
(CHEMBL518243 | lithospermic acid)
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Affinity Data
Ki: 4.80nM ΔG°: -47.5kJ/mole
T: 2°C
Assay Description:
Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration ass...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
KEGG
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Carbonic anhydrase 4
(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by
ChEMBL
Ligand
BDBM50250808
(CHEMBL518243 | lithospermic acid)
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Affinity Data
Ki: 101nM ΔG°: -39.9kJ/mole
T: 2°C
Assay Description:
Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by
ChEMBL
Ligand
BDBM50250808
(CHEMBL518243 | lithospermic acid)
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Affinity Data
Ki: 268nM ΔG°: -37.5kJ/mole
T: 2°C
Assay Description:
Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by
ChEMBL
Ligand
BDBM50250808
(CHEMBL518243 | lithospermic acid)
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Affinity Data
Ki: >1.00E+4nM ΔG°: >-28.5kJ/mole
T: 2°C
Assay Description:
Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by
ChEMBL
Ligand
BDBM50250808
(CHEMBL518243 | lithospermic acid)
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Affinity Data
Ki: >1.00E+4nM ΔG°: >-28.5kJ/mole
T: 2°C
Assay Description:
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
72 kDa type IV collagenase
(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50250808
(CHEMBL518243 | lithospermic acid)
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Affinity Data
IC50: 1.02E+4nM
Assay Description:
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI