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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 38 hits in this display   

TargetSiderophore-binding protein(Mycobacterium tuberculosis)
Universit?? Degli Studi Di Firenze

LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  600nM ΔG°:  -35.5kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  980nMAssay Description:Inhibition of human CA2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of human CA1 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Mycobacterium tuberculosis)
Universit?? Degli Studi Di Firenze

LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  1.56E+3nM ΔG°:  -33.1kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-carbonic anhydrase 1(Mycobacterium tuberculosis)
Universit?? Degli Studi Di Firenze

LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  3.03E+3nM ΔG°:  -31.5kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  5.23E+3nMAssay Description:Inhibition of human CA7 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  5.33E+3nMAssay Description:Inhibition of human CA9 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  5.96E+3nMAssay Description:Inhibition of human CA5A by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  6.68E+3nMAssay Description:Inhibition of human CA14 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  6.68E+3nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  6.72E+3nMAssay Description:Inhibition of human CA6 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  7.57E+3nMAssay Description:Inhibition of human CA3 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  7.76E+3nMAssay Description:Inhibition of human CA5B by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  8.01E+3nMAssay Description:Inhibition of human catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  8.01E+3nMAssay Description:Inhibition of human CA12 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  9.60E+3nMAssay Description:Inhibition of human CA4 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Mus musculus (mouse))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  1.01E+4nMAssay Description:Inhibition of mouse carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Mus musculus (mouse))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  1.01E+4nMAssay Description:Inhibition of mouse CA13 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  1.40E+4nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of [3H]NCS-382 binding to CaMK2alpha (unknown origin)More data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  4.41E+5nM ΔG°:  -19.2kJ/molepH: 7.4 T: 2°CAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion using s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  5.37E+5nM ΔG°:  -18.7kJ/molepH: 7.4 T: 2°CAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion using s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataKi:  1.00E+6nM IC50:  3.00E+6nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))TBA
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  140nMAssay Description:Inhibition of aldose reductase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of tyrosinase in neonatal human epidermal melanocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human tyrosinase after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human tyrosinase after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Srtm University

LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  6.80E+3nMpH: 7.6 T: 2°CAssay Description:Inhibition of xanthine oxidase (XO) by each isolated phenolics was measured by following the decrease in the uric acid formation at 293nm at 25°...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))TBA
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  7.60E+4nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B1 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL12(Saccharomyces cerevisiae)
Srtm University

LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  9.08E+4nMAssay Description:The assay was performed using isolated phenolics from maize, and inhibition was determined according to previously described method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kinki University

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  1.21E+5nMAssay Description:Inhibition of mushroom tyrosinase after 25 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-321](Homo sapiens (Human))
Chulalongkorn University

LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  1.68E+5nMpH: 7.5 T: 2°CAssay Description:PTP1B was diluted before the experiment to 1.2 μg/mL in Tris buffer, pH7.6 (10 mM Tris, 1.0 mM EDTA, 3.0 mM DTT, 0.01% w/v NaN3). The tested com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL62(Saccharomyces cerevisiae)TBA
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 10 min before substrate addition and ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-glucosidase MAL62(Saccharomyces cerevisiae)TBA
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataIC50:  2.00E+11nMAssay Description:Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEstrogen receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataEC50:  1.61E+4nMAssay Description:Agonist activity at human estrogen receptor-alpha by yeast two-hybrid assay in presence of SRC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM4374((2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | (2E)-3...)
Affinity DataEC50:  4.89E+3nMAssay Description:Agonist activity at human estrogen receptor-beta by yeast two-hybrid assay in presence of SRC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed