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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Neprilysin
(Homo sapiens (Human))
University Of Nebraska Medical Center
Curated by
ChEMBL
Ligand
BDBM50006115
((R)-RETRO-THIORPHAN | (RETRO)N-(1-Mercaptomethyl-2...)
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Affinity Data
Ki: 2.30nM
Assay Description:
Inhibition of NEP 24.11 (unknown origin) by fluorometric assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
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Target
Thermolysin
(Bacillus thermoproteolyticus)
Ciba-Geigy
Curated by
ChEMBL
Ligand
BDBM50006115
((R)-RETRO-THIORPHAN | (RETRO)N-(1-Mercaptomethyl-2...)
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Affinity Data
Ki: 2.30E+3nM
Assay Description:
Inhibitory constant against thermolysin.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
DrugBank
MMDB
PDB
3D Structure (crystal)
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Target
Neprilysin
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50006115
((R)-RETRO-THIORPHAN | (RETRO)N-(1-Mercaptomethyl-2...)
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Affinity Data
IC50: 210nM
Assay Description:
Concentration for 50% inhibition of activity of rat kidney enkephalinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
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Target
Angiotensin-converting enzyme
(Homo sapiens (Human))
University Of Michigan
Curated by
ChEMBL
Ligand
BDBM50006115
((R)-RETRO-THIORPHAN | (RETRO)N-(1-Mercaptomethyl-2...)
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Affinity Data
IC50: 1.00E+9nM
Assay Description:
Inhibition of angiotensin I converting enzyme in silico
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI