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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
26
hits in this display
Target
G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
Ki: 12nM
Assay Description:
Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis
Checked by Author
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Target
Solute carrier organic anion transporter family member 1B1
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
Ki: 450nM
Assay Description:
Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells
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Target
Solute carrier organic anion transporter family member 1B3
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
Ki: 940nM
Assay Description:
Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells
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Target
Androgen receptor
(Homo sapiens (Human))
University Of British Columbia
Curated by
ChEMBL
Ligand
BDBM78435
(4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-h...)
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Affinity Data
IC50: 400nM
Assay Description:
Inhibition of androgen receptor in human LNCaP cells assessed as inhibition of prostate-specific antigen secretion into media after 3 days
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Target
Mevalonate kinase
(Streptococcus pneumoniae D39)
Srmlsc
Curated by
PubChem BioAssay
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: 511nM
Assay Description:
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...
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Target
Mevalonate kinase
(Streptococcus pneumoniae D39)
Srmlsc
Curated by
PubChem BioAssay
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: 539nM
Assay Description:
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...
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Target
Solute carrier organic anion transporter family member 1B1
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: 813nM
Assay Description:
pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells
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Target
Solute carrier organic anion transporter family member 1B3
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: 1.23E+3nM
Assay Description:
pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells
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Target
Mitochondrial import inner membrane translocase subunit TIM23
(Saccharomyces cerevisiae S288c)
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM78435
(4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-h...)
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Affinity Data
IC50: 5.95E+3nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...
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Target
DNA polymerase beta
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: 9.00E+3nM
Assay Description:
Inhibition of DNA polymerase beta (unknown origin)
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Target
Mitochondrial import inner membrane translocase subunit TIM10
(Saccharomyces cerevisiae S288c)
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM78435
(4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-h...)
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Affinity Data
IC50: 9.45E+3nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...
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Target
Integrase
(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: 3.86E+4nM
Assay Description:
Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2
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Target
Integrase
(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: 4.58E+4nM
Assay Description:
Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1
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Target
Integrase
(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: 6.18E+4nM
Assay Description:
Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1
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Target
Integrase
(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: 7.86E+4nM
Assay Description:
Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 2
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Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Inha University
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: 3.10E+5nM
Assay Description:
Inhibition of human PTPase 1B
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Target
Tyrosine-protein phosphatase 1
(Saccharomyces cerevisiae)
Inha University
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibitory activity against Saccharomyces cerevisiae Tyrosine phosphatase 1
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Target
Mevalonate kinase
(Streptococcus pneumoniae D39)
Srmlsc
Curated by
PubChem BioAssay
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
IC50: >1.00E+7nM
Assay Description:
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...
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Target
G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
EC50: 50nM
Assay Description:
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...
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Target
G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
EC50: 2.10nM
Assay Description:
Agonist activity at human GPR35 by DMR assay
Checked by Author
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Target
G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
EC50: 2nM
Assay Description:
Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay
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Target
G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Copy SMILES
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Affinity Data
EC50: 500nM
Assay Description:
Agonist activity at human GPR35 receptor expressed in HEK293T cells co-expressing beta-arrestin2 assessed as induction of beta-arrestin2 recruitment ...
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Target
G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
EC50: 2nM
Assay Description:
Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response measured for 60 mins by DMR assay
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Target
Flavin reductase (NADPH)
(Homo sapiens)
Korea Basic Science Institute
US Patent
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
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Affinity Data
Kd: 1.80E+3nM
Assay Description:
An enzyme activity assay for BLVRB was conducted. Since BLVRB catalyzes the NAD(P)H dependent readuction of FMN, changes in the NAD(P)H concentration...
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3D Structure (crystal)
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Target
G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Copy SMILES
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Affinity Data
EC50: 1.20E+3nM
Assay Description:
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...
Checked by Author
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Target
G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM38549
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 500nM
Assay Description:
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay
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