Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 26 hits in this display   

TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataKi:  450nMAssay Description:Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataKi:  940nMAssay Description:Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM78435(4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-h...)
Affinity DataIC50:  400nMAssay Description:Inhibition of androgen receptor in human LNCaP cells assessed as inhibition of prostate-specific antigen secretion into media after 3 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMevalonate kinase(Streptococcus pneumoniae D39)
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  511nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMevalonate kinase(Streptococcus pneumoniae D39)
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  539nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  813nMAssay Description:pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  1.23E+3nMAssay Description:pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitochondrial import inner membrane translocase subunit TIM23(Saccharomyces cerevisiae S288c)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM78435(4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-h...)
Affinity DataIC50:  5.95E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDNA polymerase beta(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of DNA polymerase beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitochondrial import inner membrane translocase subunit TIM10(Saccharomyces cerevisiae S288c)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM78435(4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-h...)
Affinity DataIC50:  9.45E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  3.86E+4nMAssay Description:Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  4.58E+4nMAssay Description:Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  6.18E+4nMAssay Description:Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  7.86E+4nMAssay Description:Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50:  3.10E+5nMAssay Description:Inhibition of human PTPase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase 1(Saccharomyces cerevisiae)
Inha University

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against Saccharomyces cerevisiae Tyrosine phosphatase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMevalonate kinase(Streptococcus pneumoniae D39)
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataIC50: >1.00E+7nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at human GPR35 by DMR assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataEC50:  500nMAssay Description:Agonist activity at human GPR35 receptor expressed in HEK293T cells co-expressing beta-arrestin2 assessed as induction of beta-arrestin2 recruitment ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response measured for 60 mins by DMR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlavin reductase (NADPH)(Homo sapiens)
Korea Basic Science Institute

US Patent
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataKd:  1.80E+3nMAssay Description:An enzyme activity assay for BLVRB was conducted. Since BLVRB catalyzes the NAD(P)H dependent readuction of FMN, changes in the NAD(P)H concentration...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 35(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM38549(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Affinity DataEC50:  500nMAssay Description:Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed