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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Aurora kinase A
(Homo sapiens (Human))
Moffitt Cancer Center
Ligand
BDBM87053
(Bisanilinopyrimidine inhibitor, 7 | Bisanilinopyri...)
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Affinity Data
IC50: 2.5nM Kd: 15nM
pH: 7.4 T: 2°C
Assay Description:
The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Aurora kinase A
(Homo sapiens (Human))
Moffitt Cancer Center
Ligand
BDBM87053
(Bisanilinopyrimidine inhibitor, 7 | Bisanilinopyri...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.5nM
Assay Description:
In vitro enzyme activity assay using Aurora Kinase A.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Aurora kinase A
(Homo sapiens (Human))
Moffitt Cancer Center
Ligand
BDBM87053
(Bisanilinopyrimidine inhibitor, 7 | Bisanilinopyri...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.5nM Kd: 15nM
pH: 7.4
Assay Description:
The binding of inhibitors to Aurora A kinase was analyzed with a MicroCal iTC200 titration calorimeter (GE Healthcare, Piscataway, N.J.). The protein...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Similars
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Aurora kinase A
(Homo sapiens (Human))
Moffitt Cancer Center
Ligand
BDBM87053
(Bisanilinopyrimidine inhibitor, 7 | Bisanilinopyri...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.5nM
pH: 7.4 T: 2°C
Assay Description:
Aurora A was exchanged into 50 mM phosphate buffer (pH 7.4) including 1 mM DTT via PD-10 columns and was concentrated to 20 mg mL-1 using Amicon Ultr...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Similars
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Aurora kinase A
(Homo sapiens (Human))
Moffitt Cancer Center
Ligand
BDBM87053
(Bisanilinopyrimidine inhibitor, 7 | Bisanilinopyri...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.5nM
pH: 7.4 T: 2°C
Assay Description:
Reactions were carried out at room temperature in 15 mM HEPES buffer (pH 7.4) containing 20 mM NaCl, 1 mM EGTA, 0.02% Tween 20, 10 mM MgCl2, 5% (v/v)...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Similars
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI