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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM263976(2-{5-[(3-fluorobenzyl)oxy]-1H- pyrazol-1-yl}pyridi...)
Affinity DataIC50:  22nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM263976(2-{5-[(3-fluorobenzyl)oxy]-1H- pyrazol-1-yl}pyridi...)
Affinity DataIC50: <100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263976(2-{5-[(3-fluorobenzyl)oxy]-1H- pyrazol-1-yl}pyridi...)
Affinity DataIC50: <100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263976(2-{5-[(3-fluorobenzyl)oxy]-1H- pyrazol-1-yl}pyridi...)
Affinity DataIC50: <100nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263976(2-{5-[(3-fluorobenzyl)oxy]-1H- pyrazol-1-yl}pyridi...)
Affinity DataIC50:  430nMAssay Description:Inhibition of KDM5A (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A/5B(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM263976(2-{5-[(3-fluorobenzyl)oxy]-1H- pyrazol-1-yl}pyridi...)
Affinity DataEC50:  1.20E+4nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed