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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
28
hits in this display
Target
Muscarinic acetylcholine receptor M2
(RAT)
Oak Ridge National Laboratory
Curated by
ChEMBL
Ligand
BDBM50450592
(CHEMBL558910)
Copy SMILES
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Affinity Data
Ki: 0.0300nM
Assay Description:
Ability to displace [3H](-)-quinuclidinyl bezilate(QNB) from M2 receptor in rat heart homogenate
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Oak Ridge National Laboratory
Curated by
ChEMBL
Ligand
BDBM50450592
(CHEMBL558910)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.0300nM
Assay Description:
Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Oak Ridge National Laboratory
Curated by
ChEMBL
Ligand
BDBM50450592
(CHEMBL558910)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.0300nM
Assay Description:
Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
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Affinity Data
Ki: 0.0450nM
Assay Description:
Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig.
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.0450nM
Assay Description:
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.0510nM
Assay Description:
Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea...
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.0510nM
Assay Description:
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50450592
(CHEMBL558910)
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Copy InChI
Affinity Data
Ki: 0.150nM
Assay Description:
Displacement of [3H]pirenzepine from muscarinic acetylcholine receptor M1 in rat cortex homogenates
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50450592
(CHEMBL558910)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.150nM
Assay Description:
Displacement of [3H]pirenzepine from muscarinic M1 receptor of rat cortex homogenates.
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50450592
(CHEMBL558910)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.150nM
Assay Description:
Ability to displace [3H]pirenzepine (PZ) from M1 receptor in rat cortex homogenate
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Target
Muscarinic acetylcholine receptor M3
(RAT)
Oak Ridge National Laboratory
Curated by
ChEMBL
Ligand
BDBM50450592
(CHEMBL558910)
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Copy InChI
Affinity Data
Ki: 0.160nM
Assay Description:
Ability to displace [3H]N-methylscopolamine (NMS) from M3 receptor in rat submaxillary gland homogenate
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Oak Ridge National Laboratory
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.180nM
Assay Description:
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic receptor M1
(Bos taurus)
Nova Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.190nM
Assay Description:
Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatum
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.200nM
Assay Description:
Affinity for Muscarinic acetylcholine receptors in urinary bladder from Guinea Pig by (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB displacement.
More data for this Ligand-Target Pair
Target Info
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MMDB
NCI pathway
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KEGG
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Target
Muscarinic receptor M1
(Bos taurus)
Nova Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
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Affinity Data
Ki: 0.220nM
Assay Description:
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Oak Ridge National Laboratory
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.230nM
Assay Description:
Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Muscarinic acetylcholine receptor
(Cavia porcellus)
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.240nM
Assay Description:
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.240nM
Assay Description:
Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the parotid gland from Guin...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Muscarinic acetylcholine receptor DM1
(Drosophila melanogaster)
University Of California
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
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Copy InChI
Affinity Data
Ki: 0.5nM
Assay Description:
Displacement of [3H]AF-DX 384 from Drosophila melanogaster mAChR by scintillation counting
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor DM1
(Drosophila melanogaster)
University Of California
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.5nM
Assay Description:
Displacement of [3H]QNB from Drosophila melanogaster mAChR by scintillation counting
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic receptor M1
(Bos taurus)
Nova Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50367742
(CHEMBL1788199)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.570nM
Assay Description:
Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatum
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Oak Ridge National Laboratory
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.20nM
Assay Description:
Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor
(Cavia porcellus)
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.60nM
Assay Description:
In vitro binding affinity against against guinea pig ileum using [3H]-N-methylscopolamine
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Oak Ridge National Laboratory
Curated by
ChEMBL
Ligand
BDBM50367742
(CHEMBL1788199)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.80nM
Assay Description:
Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Oak Ridge National Laboratory
Curated by
ChEMBL
Ligand
BDBM50367742
(CHEMBL1788199)
Copy SMILES
Copy InChI
Affinity Data
Ki: 123nM
Assay Description:
Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart
More data for this Ligand-Target Pair
Target Info
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Target
Vesicular acetylcholine transporter
(Rattus norvegicus)
Kanazawa University
Curated by
ChEMBL
Ligand
BDBM50010096
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
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Affinity Data
Ki: 582nM
Assay Description:
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Oak Ridge National Laboratory
Curated by
ChEMBL
Ligand
BDBM50450592
(CHEMBL558910)
Copy SMILES
Copy InChI
Affinity Data
Kd: 0.200nM
Assay Description:
In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50450592
(CHEMBL558910)
Copy SMILES
Copy InChI
Affinity Data
Kd: 0.320nM
Assay Description:
In vitro binding affinity towards Muscarinic acetylcholine receptor M1 using [3H]QNB as radioligand from rat heart tissue
More data for this Ligand-Target Pair
Target Info
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