Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL

LigandBDBM50028225(CHEMBL3354045)Copy SMILESCopy InChI

Affinity DataIC50:  3nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCeramide glucosyltransferase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL

LigandBDBM50028225(CHEMBL3354045)Copy SMILESCopy InChI

Affinity DataIC50:  150nMAssay Description:Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramideMore data for this Ligand-Target Pair

Target InfoNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL

LigandBDBM50028225(CHEMBL3354045)Copy SMILESCopy InChI

Affinity DataIC50:  350nMAssay Description:Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetryMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI