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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231747((R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataKi:  4.71E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231719(2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol |...)
Affinity DataKi:  7.60E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231759((S)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataKi:  9.28E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231747((R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataEC50:  980nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as L-glutamate induced potensiation of intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231719(2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol |...)
Affinity DataEC50:  1.13E+3nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as L-glutamate induced potensiation of intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231759((S)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataEC50:  250nMAssay Description:Antagonist activity at mGluR5 in Sprague-Dawley rat astrocyte assessed as L-quisqualate induced potensiation of intracellular calcium level by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231759((S)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataEC50:  1.08E+3nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as L-glutamate induced potensiation of intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231719(2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol |...)
Affinity DataEC50:  490nMAssay Description:Antagonist activity at mGluR5 in Sprague-Dawley rat astrocyte assessed as L-quisqualate induced potensiation of intracellular calcium level by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231747((R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataEC50:  180nMAssay Description:Antagonist activity at mGluR5 in Sprague-Dawley rat astrocyte assessed as L-quisqualate induced potensiation of intracellular calcium level by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed