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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM50134657
((4-Benzyl-piperidin-1-yl)-(5-hydroxy-1H-indol-2-yl...)
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Affinity Data
IC50: 25nM
Assay Description:
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM50134657
((4-Benzyl-piperidin-1-yl)-(5-hydroxy-1H-indol-2-yl...)
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Copy InChI
Affinity Data
IC50: 31nM
Assay Description:
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Glutamate receptor ionotropic, NMDA 1/2B
(Homo sapiens (Human))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM50134657
((4-Benzyl-piperidin-1-yl)-(5-hydroxy-1H-indol-2-yl...)
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Affinity Data
IC50: 40nM
Assay Description:
Inhibition of N-methyl-D-aspartate glutamate receptor-evoked increase of intracellular Ca+ in cells expressing NMDA glutamate receptor 1/2B
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Glutamate receptor ionotropic, NMDA 1/2B
(Homo sapiens (Human))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM50134657
((4-Benzyl-piperidin-1-yl)-(5-hydroxy-1H-indol-2-yl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 42nM
Assay Description:
Inhibition of NMDA-evoked increased intracellular [Ca2+] in cells expressing NR1/NR2B receptor
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI