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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50065856(22-cyclopropylmethyl-8-phenoxy-14-oxa-11,22-diazah...)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]DADLE from morphine-insensitive Opioid receptor delta 1 (presence of 50 nM morphine) of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50065856(22-cyclopropylmethyl-8-phenoxy-14-oxa-11,22-diazah...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]DADLE from Opioid receptor delta 1 of rat brain membranes (DAMGO quenching mu receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50002078(CHEMBL611396)
Affinity DataKi:  6.5nMAssay Description:Binding affinity against Opioid receptor delta 1 from rat brain membranes using [3H]DADLEChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50065856(22-cyclopropylmethyl-8-phenoxy-14-oxa-11,22-diazah...)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]DADLE from morphine-sensitive Opioid receptor delta 1 (presence of 300 nM DELT-II) of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50065856(22-cyclopropylmethyl-8-phenoxy-14-oxa-11,22-diazah...)
Affinity DataKi:  175nMAssay Description:Displacement of [125I]OXY from Opioid receptor kappa 2b of guinea pig brain membranes (pretreated with BIT(mu) and FIT(delta) and in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50065856(22-cyclopropylmethyl-8-phenoxy-14-oxa-11,22-diazah...)
Affinity DataKi:  220nMAssay Description:Compound was tested for antagonist activity against Opioid receptor delta 1 on mouse vas deferens (MVD) smooth muscle preparation using DPDPE as anta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Medicine & Dentistry Of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)

Curated by ChEMBL
LigandPNGBDBM50002078(CHEMBL611396)
Affinity DataKi:  234nMAssay Description:Binding affinity against Opioid receptor mu 1 from rat brain membranes using [3H]DAMGOChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50002078(CHEMBL611396)
Affinity DataKi:  234nMAssay Description:Binding affinity against Opioid receptor kappa 1 from guinea pig brain membranes using [3H]U-69593Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Medicine & Dentistry Of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)

Curated by ChEMBL
LigandPNGBDBM50065856(22-cyclopropylmethyl-8-phenoxy-14-oxa-11,22-diazah...)
Affinity DataKi:  235nMAssay Description:Displacement of [3H]DAMGO from Opioid receptor mu 1 of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50065856(22-cyclopropylmethyl-8-phenoxy-14-oxa-11,22-diazah...)
Affinity DataKi:  236nMAssay Description:Displacement of [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brain membranes (pretreated with BIT and FIT to block mu and delta sites)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50065856(22-cyclopropylmethyl-8-phenoxy-14-oxa-11,22-diazah...)
Affinity DataIC50:  3.00E+3nMAssay Description:Partial agonist activity expressed as inhibition of contraction of mouse vas deferens (MVD) smooth muscle at 1 uM conc.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed