TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 3.40E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 3.70E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 5.80E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.30E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.50E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.60E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.80E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 5.00E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 5.80E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 7.70E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 8.30E+4nMAssay Description:Inhibition of asparaginyl hydroxylase factor-inhibiting-HIFMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.09E+5nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 1.20E+6nMAssay Description:Inhibition of asparaginyl hydroxylase factor-inhibiting-HIFMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.140nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.650nMAssay Description:Inhibition of Staphylococcus aureus FabI-mediated trans-2-octenoyl N-acetylcysteamine (t-o-NAC thioester) substrate reduction assessed as decrease in...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.650nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of HIF-1alpha in human U373 cellsMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of HIF-1alpha in human HCT116 cells under hypoxia condition by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Activation of HIF1 in human T47D cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 6.76nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 6.76nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 10.7nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Activation of HIF1 in human T47D cellsMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Activation of HIF1 in human T47D cellsMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: >30nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of HIF-1alpha-mediated VEGF expression in human Hep3b cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Binding affinity to Cys255 residue of C-terminal Avi/FLAG-tagged HIF-1alpha (unknown origin) after 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of CoCl2-induced HIF1alpha expression in mouse 4T1 cells transfected with oxygen-dependent-degradation domain of HIFalpha by luciferase re...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair