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Found 2229 Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 1D'
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413549(CHEMBL513715)
Affinity DataKi:  0.0501nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413549(CHEMBL513715)
Affinity DataKi:  0.0501nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(RAT)
University Of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50280055(50285557 | 7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(RAT)
University Of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50027065((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413560(CHEMBL469374)
Affinity DataKi:  0.0794nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417409(CHEMBL1290487)
Affinity DataKi:  0.0794nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50054988(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-[4-(4-{2-...)
Affinity DataKi:  0.0900nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413550(CHEMBL469345)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413077(CHEMBL522257)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417420(CHEMBL1290486)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50054981(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(4-{2-[3-...)
Affinity DataKi:  0.110nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50054974(2-(5-((4-((3-(2-aminoethyl)-1H-indol-5-yloxy)methy...)
Affinity DataKi:  0.110nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50054974(2-(5-((4-((3-(2-aminoethyl)-1H-indol-5-yloxy)methy...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM79215(CHEMBL15928 | GR 127935 | GR 127935 hydrochloride ...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM79215(CHEMBL15928 | GR 127935 | GR 127935 hydrochloride ...)
Affinity DataKi:  0.126nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417411(CHEMBL1290715)
Affinity DataKi:  0.126nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417424(CHEMBL1289394)
Affinity DataKi:  0.126nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50280055(50285557 | 7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-...)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50280055(50285557 | 7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-...)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413555(CHEMBL469568)
Affinity DataKi:  0.158nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413084(CHEMBL521506)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413078(CHEMBL491839)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412441(CHEMBL490417 | SB-744185)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50054987(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-...)
Affinity DataKi:  0.160nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50054976(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-{2-[3-(2-...)
Affinity DataKi:  0.180nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413553(CHEMBL472290)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413087(CHEMBL497980)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413698(CHEMBL459282)
Affinity DataKi:  0.200nMAssay Description:Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413079(CHEMBL444398)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413085(CHEMBL485491)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413075(CHEMBL489394)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412441(CHEMBL490417 | SB-744185)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50090516(5-tert-Butyl-3-((R)-1-methyl-pyrrolidin-2-ylmethyl...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413081(CHEMBL523095)
Affinity DataKi:  0.251nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413554(CHEMBL469567)
Affinity DataKi:  0.251nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413082(CHEMBL490211)
Affinity DataKi:  0.251nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413074(CHEMBL496317)
Affinity DataKi:  0.251nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50475186(CHEMBL190298)
Affinity DataKi:  0.251nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412126(CHEMBL525362)
Affinity DataKi:  0.251nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50369048(CHEMBL1203216)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50054980(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(1'-{2-[3...)
Affinity DataKi:  0.270nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50090517(5-Isopropyl-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)...)
Affinity DataKi:  0.290nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50033440(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(2-nit...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271019(4-fluoro-N-(3-{1-[7-(4-{5-[(4-fluorobenzene)amido]...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151705((4-tert-Butyl-2,6-dimethyl-phenyl)-(4,5-dihydro-1H...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50054973(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(3-{2-[3-...)
Affinity DataKi:  0.300nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50054764((E)-3-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-...)
Affinity DataKi:  0.300nMAssay Description:Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50133454(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.310nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50033443(6-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(4-ami...)
Affinity DataKi:  0.310nMAssay Description:Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413068(CHEMBL497979)
Affinity DataKi:  0.316nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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