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Found 28 Enz. Inhib. hit(s) with Target = 'Bifunctional ligase/repressor BirA'
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM161472(US9108978, 2.02)
Affinity DataKi:  30nM ΔG°:  -44.7kJ/mole IC50:  203nMpH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50039492(CHEMBL1231498)
Affinity DataKi:  87nMAssay Description:Inhibition of Escherichia coli recombinant BPL using 3H-biotin as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM161468(US9108978, 6.09)
Affinity DataKi:  90nM ΔG°:  -41.8kJ/mole IC50:  530nMpH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM92383(Biotin triazole, 14)
Affinity DataKi:  90nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM161472(US9108978, 2.02)
Affinity DataKi:  225nM ΔG°:  -39.5kJ/molepH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM161472(US9108978, 2.02)
Affinity DataKi:  420nM ΔG°:  -37.9kJ/molepH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM161470(US9108978, 4.01)
Affinity DataKi:  660nM ΔG°:  -36.7kJ/mole IC50:  4.00E+3nMpH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM161470(US9108978, 4.01)
Affinity DataKi:  660nMAssay Description:Inhibition of Staphylococcus aureus biotin protein ligase by LC/MS-SIM analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM161469(US9108978, 6.07)
Affinity DataKi:  1.17E+3nM ΔG°:  -35.2kJ/mole IC50:  7.00E+3nMpH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM92378(Biotin triazole, 5)
Affinity DataKi:  1.17E+3nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM92382(Biotin triazole, 13)
Affinity DataKi:  1.17E+3nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50514425(CHEMBL4462026)
Affinity DataKi:  1.40E+3nMAssay Description:Binding affinity to Staphylococcus aureus biotin protein ligaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM161467(US9108978, 3.25)
Affinity DataKi:  1.83E+3nM ΔG°:  -34.1kJ/mole IC50:  1.16E+4nMpH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM161471(US9108978, 6.34)
Affinity DataKi: >1.00E+4nM ΔG°: >-29.7kJ/mole IC50: >5.00E+4nMpH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM92381(Biotin triazole, 12)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM92385(Biotin triazole, 16)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM92384(Biotin triazole, 15)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM92379(Biotin triazole, 10)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Monash University

US Patent
LigandPNGBDBM92380(Biotin triazole, 11)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM161467(US9108978, 3.25)
Affinity DataKi: >3.00E+4nM ΔG°: >-26.9kJ/molepH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM161468(US9108978, 6.09)
Affinity DataKi: >3.00E+4nM ΔG°: >-26.9kJ/molepH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM161469(US9108978, 6.07)
Affinity DataKi: >3.00E+4nM ΔG°: >-26.9kJ/molepH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM161470(US9108978, 4.01)
Affinity DataKi: >3.00E+4nM ΔG°: >-26.9kJ/molepH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM161469(US9108978, 6.07)
Affinity DataKi: >3.00E+4nM ΔG°: >-26.9kJ/molepH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM161467(US9108978, 3.25)
Affinity DataKi: >3.00E+4nM ΔG°: >-26.9kJ/molepH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM161468(US9108978, 6.09)
Affinity DataKi: >3.00E+4nM ΔG°: >-26.9kJ/molepH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM161470(US9108978, 4.01)
Affinity DataKi: >3.00E+4nM ΔG°: >-26.9kJ/molepH: 8.0 T: 2°CAssay Description:Quantitation of BPL catalysed 3H-biotin incorporation into the biotin domain substrate was performed as previously described by Polyak et al, J. Biol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50039492(CHEMBL1231498)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to Escherichia coli biotin protein ligaseMore data for this Ligand-Target Pair