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Found 28 Enz. Inhib. hit(s) with Target = 'Antithrombin-III'
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50037996(1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...)
Affinity DataIC50:  570nMAssay Description:Antithrombin III (ATIII)-mediated anti-Xa activity was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III/Prothrombin(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM264613(US9718760, C157)
Affinity DataIC50:  4.44E+4nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAntithrombin-III/Prothrombin(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM264597(US9718760, C152)
Affinity DataIC50:  8.70E+4nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAntithrombin-III/Coagulation factor X(Homo sapiens (Human))
Universidade do Porto (CEQUIMED-UP)

Curated by ChEMBL
LigandPNGBDBM50393527(CHEMBL2158198)
Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of human factor 10a/antithrombin 3 assessed as CBS 31.39 substrate hydrolysis by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310312(CHEMBL597509 | N,N'-bis(3,4-dihydroxybenzenesulfon...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310299(CHEMBL599342 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-3...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310309(CHEMBL596879 | N-(3,4-dihydroxyphenylsulfonyl)-N-h...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310311(CHEMBL601265 | N-cyclohexyl-N-(3,4-dihydroxyphenyl...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310310(CHEMBL596880 | N-benzyl-N-(3,4-dihydroxyphenylsulf...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310306(CHEMBL611972 | N,N'-(ethane-1,2-diyl)bis(N-ethylbe...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310305(CHEMBL596859 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-4...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310313(CHEMBL596860 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-2...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III/Prothrombin(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM264614(US9718760, C158)
Affinity DataIC50:  5.47E+5nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310301(CHEMBL599742 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-3...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310308(CHEMBL597478 | N-(3,4-dihydroxyphenylsulfonyl)-3,4...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310304(CHEMBL597510 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-3...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III/Prothrombin(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM264648(US9718760, C161)
Affinity DataIC50:  1.67E+6nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAntithrombin-III/Prothrombin(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM264627(US9718760, C160)
Affinity DataIC50:  2.33E+6nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAntithrombin-III/Prothrombin(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM264598(US9718760, C155)
Affinity DataIC50:  2.33E+6nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310302(CHEMBL611992 | N,N'-(butane-1,4-diyl)bis(3,4-dihyd...)
Affinity DataIC50: >3.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310303(CHEMBL599769 | N,N'-(hexane-1,6-diyl)bis(3,4-dihyd...)
Affinity DataIC50: >3.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310307(CHEMBL596861 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-3...)
Affinity DataIC50: >3.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50310300(CHEMBL606451 | N,N'-(ethane-1,2-diyl)bis(3,4-dihyd...)
Affinity DataIC50: >3.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50369253(CHEMBL1909451)
Affinity DataKd:  7nMAssay Description:Dissociation constant for Antithrombin-IIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50369254(CHEMBL609990)
Affinity DataKd:  58nMAssay Description:Dissociation constant for Antithrombin-IIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50378854(IDRAPARINUX SODIUM)
Affinity DataKd:  1nMAssay Description:Binding affinity to antithrombin 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50421408(CHEMBL2303815)
Affinity DataKd:  1.90nMAssay Description:In vitro binding affinity against antithrombin III (AT III) was determined by fluorescence spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50421407(CHEMBL2303814)
Affinity DataKd:  2.80nMAssay Description:In vitro binding affinity against antithrombin III (AT III) was determined by fluorescence spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article