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Found 1959 Enz. Inhib. hit(s) with Target = 'MAP kinase-activated protein kinase 2'
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant MK2 (45 to 400 residues) (unknown origin) using fluorescein isothiocyanate-KKKALSRQLSVAA as substrateMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50323635(6-(4-chlorophenyl)-N-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataKi:  96nMAssay Description:Competitive inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50323635(6-(4-chlorophenyl)-N-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataKi:  310nMAssay Description:Uncompetitive inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50323635(6-(4-chlorophenyl)-N-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataKi:  320nMAssay Description:Mixed inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50411445(CHEMBL235658)
Affinity DataKi:  330nMAssay Description:Inhibition of MK2 in human TERT immortalised HCA2 cells assessed as inhibition of anisomycin-induced HSP27 phosphorylation at 2.5 uM by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50323635(6-(4-chlorophenyl)-N-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataKi:  480nMAssay Description:Noncompetitive inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MAPKAPK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MAPKAPK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  3.89E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50395262(CHEMBL2163999)
Affinity DataKi:  6.00E+3nMAssay Description:Competitive inhibition of MAPKAP-K2 using KKLNRTLSVA as substrate and [33P]-gamma-ATP by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50297122((R)-10-Methyl-9,10,11,12-tetrahydro-7-thia-4,9,12-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50348545(CHEMBL1801384)
Affinity DataIC50:  1nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50434486(CHEMBL2385548)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of MK2 (unknown origin) phosphorylation using TAMRA labeled peptide as substrate incubated 30 mins before substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50297124((R)-3-Chloro-10-methyl-9,10,11,12-tetrahydro-7-thi...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374681(CHEMBL257834)
Affinity DataIC50:  2nMAssay Description:Inhibition of human MK2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50:  2nMAssay Description:Inhibition of human MK2More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374683(CHEMBL258045)
Affinity DataIC50:  2nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374681(CHEMBL257834)
Affinity DataIC50:  2nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374682(CHEMBL403154)
Affinity DataIC50:  2nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50362173(CHEMBL1938685)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of MK2 using TAMRA-labeled peptide as substrate pre-incubated for 30 mins prior substrate addition measured after 30 mins incubation in da...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50434488(CHEMBL2385549)
Affinity DataIC50:  3nMAssay Description:Inhibition of MK2 (unknown origin) phosphorylation using TAMRA labeled peptide as substrate incubated 30 mins before substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50465455(CHEMBL4282514)
Affinity DataIC50: <3nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50348515(CHEMBL1233942)
Affinity DataIC50: <3nMAssay Description:Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374687(CHEMBL256194)
Affinity DataIC50:  3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50465453(CHEMBL4277929)
Affinity DataIC50: <3nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50465454(CHEMBL4293121)
Affinity DataIC50: <3nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374679(CHEMBL403258)
Affinity DataIC50:  3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50362175(CHEMBL1938687)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of MK2 using TAMRA-labeled peptide as substrate pre-incubated for 30 mins prior substrate addition measured after 30 mins incubation in da...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50348492(CHEMBL1801296)
Affinity DataIC50:  4nMAssay Description:Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374688(CHEMBL255991)
Affinity DataIC50:  4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50434494(CHEMBL2385542)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of MK2 (unknown origin) phosphorylation using TAMRA labeled peptide as substrate incubated 30 mins before substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374684(CHEMBL270148)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374680(CHEMBL429504)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50297151((3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50297113((R)-10-Methyl-3-pyridin-3-yl-9,10,11,12-tetrahydro...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50348546(CHEMBL1801385)
Affinity DataIC50:  5nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50:  5nMAssay Description:Binding affinity to recombinant MAPKAP-K2 using KKKALSRQLSVAA as substrate after 4 mins by surface plasmon resonance spectroscopic analysisMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374693(CHEMBL271309)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50348542(CHEMBL1801381)
Affinity DataIC50:  5nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50348543(CHEMBL1801382)
Affinity DataIC50:  5nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50297119((R)-10-Methyl-3-(4-methyl-pyridin-3-yl)-9,10,11,12...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50434489(CHEMBL2385547)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of MK2 (unknown origin) incubated for 30 mins by MK2 IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50434489(CHEMBL2385547)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of MK2 (unknown origin) phosphorylation using TAMRA labeled peptide as substrate incubated 30 mins before substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50348493(CHEMBL1801304)
Affinity DataIC50:  6nMAssay Description:Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50348491(CHEMBL1801305)
Affinity DataIC50:  6nMAssay Description:Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50384542(CHEMBL2036616)
Affinity DataIC50:  6nMAssay Description:Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50560259(CHEMBL4792347)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human MAPKAPK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [46-400](Homo sapiens (Human))
Xinthera

US Patent
LigandPNGBDBM605814(US11680056, Example 5 | US11680056, Example 5A | U...)
Affinity DataIC50:  6.31nMAssay Description:This study evaluates the inhibitory potency of invention compound on p38/MK2 pathway vs p38/PRAK pathway. More specially the compound concentration (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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