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Found 3504 Enz. Inhib. hit(s) with Target = 'ATP-dependent translocase ABCB1'
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataKi:  20nMAssay Description:Binding affinity to Vanadate-sensitive ABCB1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataKi:  20nMAssay Description:TP_TRANSPORTER: inhibition of Verapamil stimulated ATP hydrolysis in membranes from MDR1-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50206310(5-Methoxy-9-oxo-9,10-dihydro-acridine-4-carboxylic...)
Affinity DataKi:  40nMAssay Description:TP_TRANSPORTER: transepithelial transport of digoxin (basal to apical) in Caco-2 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50012278((2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLAS...)
Affinity DataKi:  100nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataKi:  100nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50121978(2-(6-Amino-3-imino-3H-xanthen-9-yl)-benzoic acid m...)
Affinity DataKi:  100nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50017712((-)-reserpine | (3beta,16beta,17alpha,18beta,20alp...)
Affinity DataKi:  100nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50115973(CHEMBL3612151)
Affinity DataKi:  120nMAssay Description:Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50115974(CHEMBL3612170)
Affinity DataKi:  120nMAssay Description:Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153727(CHEMBL3774695)
Affinity DataKi:  130nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50390978(VALSPODAR)
Affinity DataKi:  134nMAssay Description:TP_TRANSPORTER: inhibition of ATPase activity (Verapamil) in P-gp-MRP-16-Protein A complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153737(CHEMBL3774786)
Affinity DataKi:  190nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  200nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50420182(CHEMBL2074650)
Affinity DataKi:  210nMAssay Description:TP_TRANSPORTER: inhibition of Hydroxydoxorubicin efflux in K562/Adr cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50115977(CHEMBL3612153)
Affinity DataKi:  220nMAssay Description:Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50115978(CHEMBL3612172)
Affinity DataKi:  220nMAssay Description:Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153735(CHEMBL3774970)
Affinity DataKi:  230nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153725(CHEMBL3775153)
Affinity DataKi:  240nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153733(CHEMBL3775128)
Affinity DataKi:  250nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153736(CHEMBL3775201)
Affinity DataKi:  260nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153718(CHEMBL450532)
Affinity DataKi:  280nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50486029(CHEMBL2172398)
Affinity DataKi:  280nMAssay Description:Competitive inhibition of P-gp overexpressed in human MDA435/LCC6MDR cells assessed as accumulation of doxorubicin by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50088574(CHEMBL3577218)
Affinity DataKi:  290nMAssay Description:Inhibition of human MDR1 transfected in mouse NIH/3T3 MDR1-G185 cells assessed as reduction in daunomycin accumulation after 30 mins by flow cytometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153719(CHEMBL499498)
Affinity DataKi:  290nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50005628((S) Verapamil | (S)-5-((3,4-dimethoxyphenethyl)(me...)
Affinity DataKi:  300nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50154916(CHEMBL3775786)
Affinity DataKi:  310nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153721(CHEMBL3775788)
Affinity DataKi:  310nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50115972(CHEMBL3612169)
Affinity DataKi:  320nMAssay Description:Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153723(CHEMBL3775488)
Affinity DataKi:  320nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50115971(CHEMBL3612150)
Affinity DataKi:  320nMAssay Description:Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50486029(CHEMBL2172398)
Affinity DataKi:  340nMAssay Description:Competitive inhibition of P-gp overexpressed in human MDA435/LCC6MDR cells assessed as accumulation of doxorubicin by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50353597(CHEMBL1829396)
Affinity DataKi:  340nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH-3T3 cells assessed as daunomycin efflux after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataKi:  350nMAssay Description:TP_TRANSPORTER: transepithelial transport of digoxin (basal to apical) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50353602(CHEMBL1829522)
Affinity DataKi:  380nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH-3T3 cells assessed as daunomycin efflux after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50353600(CHEMBL1829520)
Affinity DataKi:  390nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH-3T3 cells assessed as daunomycin efflux after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50485592(CHEMBL350445)
Affinity DataKi:  400nMAssay Description:TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50154912(CHEMBL3774875)
Affinity DataKi:  400nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153724(CHEMBL3774484)
Affinity DataKi:  410nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50088576(CHEMBL3577215)
Affinity DataKi:  420nMAssay Description:Inhibition of human MDR1 transfected in mouse NIH/3T3 MDR1-G185 cells assessed as reduction in daunomycin accumulation after 30 mins by flow cytometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153734(CHEMBL3775696)
Affinity DataKi:  420nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50275947((5S,14R,19S,28R)-10,23-dimethoxy-4,4,29,29-tetrame...)
Affinity DataKi:  420nMAssay Description:Inhibition of human MDR1 overexpressed in mouse NIH/3T3 cells assessed as daunorubicin accumulation by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataKi:  430nMAssay Description:TP_TRANSPORTER: transepithelial transport of digoxin (basal to apical) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50206310(5-Methoxy-9-oxo-9,10-dihydro-acridine-4-carboxylic...)
Affinity DataKi:  440nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) in MDR1-expressing MDCK cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50153738(CHEMBL3775556)
Affinity DataKi:  460nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50115976(CHEMBL3612171)
Affinity DataKi:  470nMAssay Description:Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50115975(CHEMBL3612152)
Affinity DataKi:  470nMAssay Description:Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50353599(CHEMBL1829518)
Affinity DataKi:  470nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH-3T3 cells assessed as daunomycin efflux after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50154913(CHEMBL3775570)
Affinity DataKi:  470nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH/3T3 cells assessed as inhibition of daunomycin efflux incubated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50116013(CHEMBL3612141)
Affinity DataKi:  480nMAssay Description:Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital

Curated by ChEMBL
LigandPNGBDBM50116014(CHEMBL3612160)
Affinity DataKi:  480nMAssay Description:Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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