Found 87 Enz. Inhib. hit(s) with Target = 'Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha''
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'/cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Inhibition of recombinant human His6-tagged PDE5A (535 to 786 residues)/PDE6C expressed in Escherichia coli BL21-CodonPlus cells using [3H]cGMP as su...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'/cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Inhibition of recombinant human His6-tagged PDE5A (535 to 786 residues)/PDE6C expressed in Escherichia coli BL21-CodonPlus cells using [3H]cGMP as su...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'/cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataKi: 8.50E+3nMAssay Description:Inhibition of recombinant human His6-tagged PDE5A (535 to 786 residues)/PDE6C expressed in Escherichia coli BL21-CodonPlus cells using [3H]cGMP as su...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'/cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataKi: 8.50E+3nMAssay Description:Inhibition of recombinant human His6-tagged PDE5A (535 to 786 residues)/PDE6C expressed in Escherichia coli BL21-CodonPlus cells using [3H]cGMP as su...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Inhibition of recombinant N-terminal GST tagged PDE6C (unknown origin) expressed in baculovirus infected Sf9 cells using cGMP as substrate by malachi...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PDE6C catalytic domain (1 to 858 residues) (unknown origin) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PDE6C (unknown origin) using FAM-cGMP as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant N-terminal GST tagged PDE6C (unknown origin) expressed in baculovirus infected Sf9 cells using cGMP as substrate by malachi...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibition of PDE2A1 (unknown origin) using fluorescently labeled cAMP substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 6.60nMAssay Description:Concentration required to inhibit the activity of K+ stimulated gastric ATPaseMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal GST-tagged human PDE6C expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sci...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assayMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant PDE6C using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of N-terminal GST-tagged human PDE6C expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sci...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant PDE6C at 1 uM by [3H]cGMP based tritium scintillation proximity assayMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of human recombinant PDE6C at 1 uM by [3H]cGMP based tritium scintillation proximity assayMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 107nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 127nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 136nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human PDE6CMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 253nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 288nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 402nMAssay Description:Inhibition of N-terminal GST-tagged human PDE6C expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sci...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 460nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cellsMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE6C expressed in baculovirus infected Sf9 insect cells using [3H]cGMP as substrat...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human PDE6C assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE6C (unknown origin) expressed in Baculovirus infected Sf9 insect cells using cGMP as substrateMore data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE6C (1 to 858 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method rela...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
University Of Navarra
Curated by ChEMBL
University Of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length GST-tagged PDE6C (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as substr...More data for this Ligand-Target Pair