Found 71 Enz. Inhib. hit(s) with Target = 'Small conductance calcium-activated potassium channel protein 2'
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataKi: 90nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataKi: 194nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataKi: 397nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataKi: 593nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataKi: 878nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataIC50: 123nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Inhibition of Kca2.2 channel (unknown origin) expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataIC50: 543nMAssay Description:Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Kca2.2 channel (unknown origin) expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of cloned rat SK2 channel expressed in human HEK293 cells by patch clamp assay in the presence of 1 uM intracellular Ca2+More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of SK2 expressed in CHO FlipIn cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Homo sapiens (Human))
University Of Li£Ge
Curated by ChEMBL
University Of Li£Ge
Curated by ChEMBL
Affinity DataKd: 47nMAssay Description:Inhibition of human SK2 channel by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 1.40E+4nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 0.0240nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 0.290nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 0.0270nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 4.97E+4nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 7.48E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 5.03E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 1.89E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 990nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
TargetSmall conductance calcium-activated potassium channel protein 2(Rattus norvegicus (Rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 1.99E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair