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Found 128 Enz. Inhib. hit(s) with Target = 'Spike glycoprotein'
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM50590308(CHEMBL5201689)
Affinity DataKi:  3.02E+3nMAssay Description:Competitive inhibition of biotinylated heparin binding to His-tagged wild type SARS-COV-2 spike protein assessed inhibition constant incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM50568789(Hypocrellin A | Rel-Hypocrellin A)
Affinity DataIC50:  38nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50559137(CHEMBL4785828)
Affinity DataIC50:  100nMAssay Description:Inhibition of spike protein in SARS-CoV infected in human HeLa cells haboring wild type ACE2 assessed as reduction in virus infectivity preincubated ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM50422742(CHEMBL5274408)
Affinity DataIC50:  100nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM50568790(CHEMBL4869623)
Affinity DataIC50:  120nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Affinity DataIC50:  160nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM50568791(CHEMBL4861894)
Affinity DataIC50:  170nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571394(4-chloro-N-(4-((4-hydroxypiperidin-1-yl)methyl)phe...)
Affinity DataIC50:  200nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571393(4-chloro-N-(4-(((3aR,6aS)-tetrahydro-1H-furo[3,4-c...)
Affinity DataIC50:  200nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571386(N-(4-((1,4-oxazepan-4-yl)methyl)phenyl)-4-chlorobe...)
Affinity DataIC50:  600nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM50421867(CHEMBL216826)
Affinity DataIC50:  600nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571386(N-(4-((1,4-oxazepan-4-yl)methyl)phenyl)-4-chlorobe...)
Affinity DataIC50:  700nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571396(4-chloro-N-(4-((4-methylpiperazin-1-yl)methyl)phen...)
Affinity DataIC50:  700nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571390(N-(4-((7-oxa-2-azaspiro[3.5]nonan-2-yl)methyl)phen...)
Affinity DataIC50:  700nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571387(N-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phe...)
Affinity DataIC50:  1.00E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571389(2-chloro-N-(4-(morpholinomethyl)phenyl)pyrimidine-...)
Affinity DataIC50:  1.20E+3nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571387(N-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phe...)
Affinity DataIC50:  1.20E+3nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571393(4-chloro-N-(4-(((3aR,6aS)-tetrahydro-1H-furo[3,4-c...)
Affinity DataIC50:  1.30E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571390(N-(4-((7-oxa-2-azaspiro[3.5]nonan-2-yl)methyl)phen...)
Affinity DataIC50:  1.40E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571394(4-chloro-N-(4-((4-hydroxypiperidin-1-yl)methyl)phe...)
Affinity DataIC50:  1.60E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571386(N-(4-((1,4-oxazepan-4-yl)methyl)phenyl)-4-chlorobe...)
Affinity DataIC50:  1.80E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571394(4-chloro-N-(4-((4-hydroxypiperidin-1-yl)methyl)phe...)
Affinity DataIC50:  2.10E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571390(N-(4-((7-oxa-2-azaspiro[3.5]nonan-2-yl)methyl)phen...)
Affinity DataIC50:  2.10E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571396(4-chloro-N-(4-((4-methylpiperazin-1-yl)methyl)phen...)
Affinity DataIC50:  2.70E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571393(4-chloro-N-(4-(((3aR,6aS)-tetrahydro-1H-furo[3,4-c...)
Affinity DataIC50:  2.80E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571391(N-(4-((1-oxa-7-azaspiro[4.4]nonan-7-yl)methyl)phen...)
Affinity DataIC50:  2.90E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571392(N-(4-(((1R,5S)-3-oxa-7-azabicyclo[3.3.1]nonan-7-yl...)
Affinity DataIC50:  3.10E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571395(4-chloro-N-(4-((3-hydroxypyrrolidin-1-yl)methyl)ph...)
Affinity DataIC50:  3.40E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571396(4-chloro-N-(4-((4-methylpiperazin-1-yl)methyl)phen...)
Affinity DataIC50:  3.60E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50233805(CHEMBL4077922 | US11021454, Compound Salvianolic a...)
Affinity DataIC50:  3.85E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM83797(6-Bromo-4-dimethylaminomethyl-5-hydroxy-1-methyl-2...)
Affinity DataIC50:  4.11E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM540829((3-(4-chlorophenyl) isoxazol-5-yl) methyl-(2alpha,...)
Affinity DataIC50:  4.12E+3nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567444(CHEMBL4873011)
Affinity DataIC50:  4.37E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM428875(med.21724, Compound 2)
Affinity DataIC50:  4.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567440(CHEMBL4847112)
Affinity DataIC50:  5.54E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM32188(CLIOQUINOL | Clioquinol (CQ) | TG2-36-2 | cid_2788)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of SARS-COV2 ACE2 binding to spike glycoprotein S RBD domain preincubated for 31 mins with RBD followed by protein addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567449(CHEMBL4874301)
Affinity DataIC50:  5.68E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(MERS-CoV)
University Of Bonn

LigandPNGBDBM50017696((2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiaz...)
Affinity DataIC50:  5.86E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567447(CHEMBL4852531)
Affinity DataIC50:  5.89E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567443(CHEMBL4852791)
Affinity DataIC50:  6.27E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567450(CHEMBL4859094)
Affinity DataIC50:  6.32E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571391(N-(4-((1-oxa-7-azaspiro[4.4]nonan-7-yl)methyl)phen...)
Affinity DataIC50:  6.40E+3nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567453(CHEMBL4865746)
Affinity DataIC50:  7.37E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567448(CHEMBL4875210)
Affinity DataIC50:  7.76E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571387(N-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phe...)
Affinity DataIC50:  7.80E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567441(CHEMBL4855702)
Affinity DataIC50:  8.33E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM571389(2-chloro-N-(4-(morpholinomethyl)phenyl)pyrimidine-...)
Affinity DataIC50:  9.40E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(MERS-CoV)
University Of Bonn

LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataIC50:  9.51E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567451(CHEMBL4868650)
Affinity DataIC50:  9.57E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50567442(CHEMBL4865677)
Affinity DataIC50:  9.97E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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