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Found 362 Enz. Inhib. hit(s) with Target = 'Ubiquitin carboxyl-terminal hydrolase isozyme L1'
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Mus musculus (Mouse))
Brigham And Women'S Hospital

LigandPNGBDBM53441(MLS001000876 | N-(1H-benzimidazol-2-yl)-3-chlorany...)
Affinity DataKi:  400nM ΔG°:  -36.5kJ/mole IC50:  880nMpH: 7.6 T: 2°CAssay Description:Inhibition activity and selectivity for UCH-L1 and UCH-L3.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50514120(CHEMBL3407553)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of UCHL1 in human H1299 cells using Ub-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411563(CHEMBL540117)
Affinity DataKi:  740nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411574(CHEMBL553923)
Affinity DataKi:  910nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411577(CHEMBL536998)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411568(CHEMBL536764)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411581(CHEMBL537224)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411570(CHEMBL537225)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50326016(3-amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]py...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50326016(3-amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]py...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411572(CHEMBL539345)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411573(CHEMBL557989)
Affinity DataKi:  5.30E+3nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411575(CHEMBL536763)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411579(CHEMBL539346)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411566(CHEMBL536995)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411567(CHEMBL537227)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411578(CHEMBL539094)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411580(CHEMBL557988)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411562(CHEMBL540118)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411571(CHEMBL537226)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411576(CHEMBL556784)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411569(CHEMBL538583)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50411564(CHEMBL536997)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of UCHL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445149((2S,4S)-4-Fluoro-2-(4-(5-methyl-1H-pyrazol-4-yl)in...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM552974((2S,4S)-4-fluoro-2-(4-(5- | US11319287, Example 29)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445160((S)-2-(4-(1H-pyrrolo[2,3-b]- pyridin-4-yl)indoline...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445158((S)-2-(5-(3-(trifluoro- methyl)-1H-pyrazol-4- yl)i...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445088((S)-2-(4-(1H-pyrrolo [2,3-b]pyridin-3- yl)indoline...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445080((S)-2-(4-(5-(Trifluoromethyl)-1H-pyrazol-4-yl)indo...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445080((S)-2-(4-(5-(Trifluoromethyl)-1H-pyrazol-4-yl)indo...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445088((S)-2-(4-(1H-pyrrolo [2,3-b]pyridin-3- yl)indoline...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445090((2S,4S)-4-fluoro-2-(4-(5-(trifluoromethyl)-1H-pyra...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445149((2S,4S)-4-Fluoro-2-(4-(5-methyl-1H-pyrazol-4-yl)in...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445158((S)-2-(5-(3-(trifluoro- methyl)-1H-pyrazol-4- yl)i...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445160((S)-2-(4-(1H-pyrrolo[2,3-b]- pyridin-4-yl)indoline...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50594734(CHEMBL5191704)
Affinity DataIC50:  230nMAssay Description:Inhibition of UCHL1 (unknown origin) using Ub-Rho-morpholine as substrate preincubated for 30 mins followed by substrate addition by fluorescence bas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50589875(8RK64)
Affinity DataIC50:  230nMAssay Description:Inhibition of UCHL1 (unknown origin) using Ub-Rho-Morpholine as substrate preincubated with enzyme for 1 hr followed by substrate addition and measur...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50589875(8RK64)
Affinity DataIC50:  230nMAssay Description:Inhibition of UCHL1 (unknown origin) using Ub-AMC as substrate preincubated with enzyme for 1 hr followed by substrate addition and measured for 1 hr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445098((S)-2-(4-(3-cyclopropyl-1H- pyrazol-4-yl)indoline-...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445099((S)-2-(4-(2-aminopyrimidin- 4-yl)indoline-1- carbo...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445100((S)-2-(4-(Pyridin-4-yl)indoline-1-carbonyl)pyrroli...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445107((S)-1-Cyano-N-(4-(2-methoxyphenyl)thiazol-2-yl)-N-...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445108((S)-1-cyano-N-(4-(3- methoxyphenyl)thiazol-2- yl)-...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445113((S)-N-(4-(3-chlorophenyl)- thiazol-2-yl)-1-cyano-N...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445114((S)-N-(4-(2-chlorophenyl)- thiazol-2-yl)-1-cyano-N...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445115((S)-1-cyano-N-methyl-N-(4-phenylthiazol-2-yl)pyrro...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445132((2S,4S)-1-Cyano-4-methoxy-N-methyl-N-(4-phenylthia...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445135(4-(1-(Cyano-L-prolyl)indolin-4-yl)-1H-pyrazole-5-c...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445137((S)-2-(4-(2-Aminopyridin-4-yl)indoline-1-carbonyl)...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM445140((S)-1-cyano-N-(4- (6-methoxypyridin- 2-yl)thiazol-...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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