Compile Data Set for Download or QSAR
maximum 50k data
Found 460 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 2 subunit alpha'
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50030510(CHEMBL299668 | [1-Benzyl-7-chloro-1H-quinolin-(4E)...)
Affinity DataKi:  9nMAssay Description:Inhibition of rat brain voltage-gated sodium channel subunit alpha Nav1.2-mediated current expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50022784((R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM82071(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50171290(5-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50133817(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50049750((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50094703(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM21280(5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)met...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM152638(4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50488718(CHEMBL2298874)
Affinity DataKi:  1.83E+4nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50488723(CHEMBL2298877)
Affinity DataKi:  2.03E+4nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50488721(CHEMBL2430974)
Affinity DataKi:  2.18E+4nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM45791(4-(1,3-dioxo-2-isoindolyl)benzoic acid | 4-(1,3-di...)
Affinity DataKi:  5.04E+4nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50101816(CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...)
Affinity DataKi:  5.34E+4nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50488724(CHEMBL2298875)
Affinity DataKi:  6.11E+4nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50488720(CHEMBL27783)
Affinity DataKi:  6.56E+4nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50488717(CHEMBL1972820)
Affinity DataKi:  7.84E+4nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50488719(CHEMBL2298876)
Affinity DataKi:  1.08E+5nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50488722(CHEMBL97672)
Affinity DataKi:  1.34E+5nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50488725(N-Phthaloylanthranilic Acid)
Affinity DataKi:  3.38E+5nMAssay Description:Binding affinity to Nav 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of NaV1.2 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50118514(CHEMBL3617063 | US9481677, 38)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50233223(CHEMBL4060338)
Affinity DataIC50:  0.280nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced tail current by whole cell patch clamp method re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50233223(CHEMBL4060338)
Affinity DataIC50:  0.450nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50233224(CHEMBL4070670)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced tail current by whole cell patch clamp method re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50233224(CHEMBL4070670)
Affinity DataIC50:  2.10nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human Nav1.2 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50051090(CHEMBL3318149)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50051091(CHEMBL3318150)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50051089(CHEMBL3318148)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50169425(CHEMBL3341983 | US9481677, 44)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM268418(N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...)
Affinity DataIC50:  7nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50233222(CHEMBL4082248)
Affinity DataIC50:  7.5nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50051088(CHEMBL3318147)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50051075(CHEMBL3318134)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM268527(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)
Affinity DataIC50:  10nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50:  12nMAssay Description:Inhibition of human Nav1.2 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Na+ influx in chinese hamster ovary cells expressing rat brain sodium channel type IIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM268423(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Affinity DataIC50:  14nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  19nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  20nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50051077(CHEMBL3318136)
Affinity DataIC50:  24nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Sanofi-Synthelabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM50233221(CHEMBL4064160)
Affinity DataIC50:  26nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Institute Of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50051084(CHEMBL3318143)
Affinity DataIC50:  28nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 460 total ) | Next | Last >>
Jump to: