Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50462572![]() (CHEMBL4249337) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523629![]() (CHEMBL4564327) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523642![]() (CHEMBL4539612) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523646![]() (CHEMBL4541714) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523655![]() (CHEMBL4577464) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523643![]() (CHEMBL4454890) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435525![]() ((2R,3S,4R,5R)-2-(((2-amino-3- bromoquinolin-7-yl)o...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523663![]() (CHEMBL4536042) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435509![]() ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523641![]() (CHEMBL4543007) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435657![]() ((2R,3S,4R,5R)-2-(((2-amino-3- bromoquinolin-7-yl)o...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523656![]() (CHEMBL4579773) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435523![]() ((2R,3S,4R,5R)-5-(4-amino-5-fluoro-7H- pyrrolo[2,3-...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435710![]() ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM415554![]() ((2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidi...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM415556![]() (US10428104, Example 87) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435709![]() ((2R,3S,4R,5R)-3-methyl-5-(4-methyl-7H- pyrrolo[2,3...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435524![]() ((2R,3S,4R,5R)-2-(((2-aminoquinolin-7- yl)oxy)methy...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435651![]() ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435518![]() ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435516![]() ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM415529![]() ((Scheme R) (2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-py...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523636![]() (CHEMBL4457371) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523639![]() (CHEMBL4460965) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523653![]() (CHEMBL4582424) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435705![]() ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM415556![]() (US10428104, Example 87) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovir... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435560![]() ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523644![]() (CHEMBL4541070) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435655![]() ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM178166![]() (US10307413, Compound 208 | US10391089, Compound 20...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Jinan Curated by ChEMBL | Assay Description Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H4 as substrate preincubated for 60 mins in presence of enzyme and SAM | Bioorg Med Chem Lett 28: 3693-3699 (2018) Article DOI: 10.1016/j.bmcl.2018.10.026 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523630![]() (CHEMBL4439077) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435704![]() ((2R,3S,4R,5R)-2-((R)-hydroxy(4- (trifluoromethyl)p...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523634![]() (CHEMBL4540972) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50529897![]() (CHEMBL4468383) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H... | Eur J Med Chem 164: 317-333 (2019) Article DOI: 10.1016/j.ejmech.2018.12.065 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50529897![]() (CHEMBL4468383) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H... | Eur J Med Chem 164: 317-333 (2019) Article DOI: 10.1016/j.ejmech.2018.12.065 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435520![]() ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523659![]() (CHEMBL4557058) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50366992![]() (CHEMBL4168754) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovir... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435571![]() (7-((2R,3R,4S,5R)-5-(((2-aminoquinolin-7- yl)oxy)me...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50502498![]() (CHEMBL4518534) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of human recombinant PRMT5/MEP50 expressed in baculovirus infected High-five cells using histone 4 peptide as substrate in presence of [3H... | ACS Med Chem Lett 10: 1033-1038 (2019) Article DOI: 10.1021/acsmedchemlett.9b00074 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50529901![]() (CHEMBL4568997) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H... | Eur J Med Chem 164: 317-333 (2019) Article DOI: 10.1016/j.ejmech.2018.12.065 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435659![]() ((2R,3S,4R,5R)-2-((R)-(4-chloro-3- methylphenyl)(hy...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM435700![]() ((2R,3S,4R,5R)-2-((R)-(3,4- dichlorophenyl)(hydroxy...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Incorporated US Patent | Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,... | US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50529901![]() (CHEMBL4568997) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H... | Eur J Med Chem 164: 317-333 (2019) Article DOI: 10.1016/j.ejmech.2018.12.065 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50529900![]() (CHEMBL4473655) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H... | Eur J Med Chem 164: 317-333 (2019) Article DOI: 10.1016/j.ejmech.2018.12.065 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50529900![]() (CHEMBL4473655) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H... | Eur J Med Chem 164: 317-333 (2019) Article DOI: 10.1016/j.ejmech.2018.12.065 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50529896![]() (CHEMBL4444027) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H... | Eur J Med Chem 164: 317-333 (2019) Article DOI: 10.1016/j.ejmech.2018.12.065 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50529896![]() (CHEMBL4444027) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H... | Eur J Med Chem 164: 317-333 (2019) Article DOI: 10.1016/j.ejmech.2018.12.065 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM50523635![]() (CHEMBL4556400) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Prelude Therapeutics Curated by ChEMBL | Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec... | Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 | |||||||||||
More data for this Ligand-Target Pair |
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