Found 4 hits of kd for UniProtKB: A0A024R0H7 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
PRMT5/MEP50 Enzyme
(Homo sapiens (Human)) | BDBM50366992
 (CHEMBL4168754)Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccccc2)[C@@H](O)[C@H]1O Show InChI InChI=1S/C17H18N4O4/c18-15-10-6-7-21(16(10)20-8-19-15)17-13(24)12(23)14(25-17)11(22)9-4-2-1-3-5-9/h1-8,11-14,17,22-24H,(H2,18,19,20)/t11-,12+,13-,14-,17-/m1/s1 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of PRMT5/MEP50 complex (unknown origin) expressed in Sf9 insect cells using SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin as substrate by surface plasm... |
ACS Med Chem Lett 9: 612-617 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00014 BindingDB Entry DOI: 10.7270/Q2TF00XN |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
PRMT5/MEP50 Enzyme
(Homo sapiens (Human)) | BDBM50238541
 (CHEMBL4092336)Show SMILES COC(=O)c1ccccc1NC(=O)CSc1nc2cc(OC)ccc2[nH]1 Show InChI InChI=1S/C18H17N3O4S/c1-24-11-7-8-14-15(9-11)21-18(20-14)26-10-16(22)19-13-6-4-3-5-12(13)17(23)25-2/h3-9H,10H2,1-2H3,(H,19,22)(H,20,21) | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 987 | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description Binding affinity to PRMT5/MEP50 (unknown origin) by surface plasmon resonance assay |
J Med Chem 60: 6289-6304 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW |
More data for this Ligand-Target Pair | |
PRMT5/MEP50 Enzyme
(Homo sapiens (Human)) | BDBM50506814
 (CHEMBL4513619)Show InChI InChI=1S/C19H18BrN3O/c20-17-6-3-7-18(16(17)12-21)22-19(24)9-11-23-10-8-14-4-1-2-5-15(14)13-23/h1-7H,8-11,13H2,(H,22,24) | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a |
University of Jinan
Curated by ChEMBL
| Assay Description Binding affinity to PRMT5 (unknown origin)/MEP50 (unknown origin) by SPR assay |
Bioorg Med Chem Lett 28: 3693-3699 (2018)
Article DOI: 10.1016/j.bmcl.2018.10.026 |
More data for this Ligand-Target Pair | |
PRMT5/MEP50 Enzyme
(Homo sapiens (Human)) | BDBM50089221
 (CHEMBL3577854)Show SMILES CCNC(=O)NCCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 Show InChI InChI=1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10-,11-,14-/m1/s1 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description Binding affinity to human full length PRMT5-MEP50 complex by Surface plasmon resonance method |
ACS Med Chem Lett 6: 408-12 (2015)
Article DOI: 10.1021/ml500467h BindingDB Entry DOI: 10.7270/Q2Q81FSZ |
More data for this Ligand-Target Pair | |