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Compile Data Set for Download or QSAR

Found 4 hits of kd for UniProtKB: A0A024R0H7   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM50366992
PNG
(CHEMBL4168754)
Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccccc2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H18N4O4/c18-15-10-6-7-21(16(10)20-8-19-15)17-13(24)12(23)14(25-17)11(22)9-4-2-1-3-5-9/h1-8,11-14,17,22-24H,(H2,18,19,20)/t11-,12+,13-,14-,17-/m1/s1
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n/an/an/a 6n/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PRMT5/MEP50 complex (unknown origin) expressed in Sf9 insect cells using SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin as substrate by surface plasm...


ACS Med Chem Lett 9: 612-617 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00014
BindingDB Entry DOI: 10.7270/Q2TF00XN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM50238541
PNG
(CHEMBL4092336)
Show SMILES COC(=O)c1ccccc1NC(=O)CSc1nc2cc(OC)ccc2[nH]1
Show InChI InChI=1S/C18H17N3O4S/c1-24-11-7-8-14-15(9-11)21-18(20-14)26-10-16(22)19-13-6-4-3-5-12(13)17(23)25-2/h3-9H,10H2,1-2H3,(H,19,22)(H,20,21)
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n/an/an/a 987n/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Binding affinity to PRMT5/MEP50 (unknown origin) by surface plasmon resonance assay


J Med Chem 60: 6289-6304 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00587
BindingDB Entry DOI: 10.7270/Q2D220XW
More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM50506814
PNG
(CHEMBL4513619)
Show SMILES Brc1cccc(NC(=O)CCN2CCc3ccccc3C2)c1C#N
Show InChI InChI=1S/C19H18BrN3O/c20-17-6-3-7-18(16(17)12-21)22-19(24)9-11-23-10-8-14-4-1-2-5-15(14)13-23/h1-7H,8-11,13H2,(H,22,24)
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n/an/an/a 1.08E+4n/an/an/an/an/a



University of Jinan

Curated by ChEMBL


Assay Description
Binding affinity to PRMT5 (unknown origin)/MEP50 (unknown origin) by SPR assay


Bioorg Med Chem Lett 28: 3693-3699 (2018)


Article DOI: 10.1016/j.bmcl.2018.10.026
More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM50089221
PNG
(CHEMBL3577854)
Show SMILES CCNC(=O)NCCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10-,11-,14-/m1/s1
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n/an/an/a 2.50E+4n/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Binding affinity to human full length PRMT5-MEP50 complex by Surface plasmon resonance method


ACS Med Chem Lett 6: 408-12 (2015)


Article DOI: 10.1021/ml500467h
BindingDB Entry DOI: 10.7270/Q2Q81FSZ
More data for this
Ligand-Target Pair