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Compile Data Set for Download or QSAR

Found 4 hits of ec50 for monomerid = 50206009   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NR1/NR2A


(Homo sapiens (Human))
BDBM50206009
PNG
(CHEMBL3983039 | US10280165, Example 35)
Show SMILES Cc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C18H13ClF3N5O/c1-9-2-3-15-24-11(8-26-14(19)6-13(25-26)18(20,21)22)5-16(28)27(15)17(9)12-4-10(12)7-23/h2-3,5-6,10,12H,4,8H2,1H3/t10-,12+/m0/s1
PDB
MMDB

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PC sid
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Article
PubMed
n/an/an/an/a 41n/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
NR1/NR2A


(Homo sapiens (Human))
BDBM50206009
PNG
(CHEMBL3983039 | US10280165, Example 35)
Show SMILES Cc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C18H13ClF3N5O/c1-9-2-3-15-24-11(8-26-14(19)6-13(25-26)18(20,21)22)5-16(28)27(15)17(9)12-4-10(12)7-23/h2-3,5-6,10,12H,4,8H2,1H3/t10-,12+/m0/s1
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US Patent
n/an/an/an/a 77n/an/an/an/a



Genentech Inc

US Patent


Assay Description
TBD


US Patent US10280165 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor AMPA 2/3


(Homo sapiens (Human))
BDBM50206009
PNG
(CHEMBL3983039 | US10280165, Example 35)
Show SMILES Cc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C18H13ClF3N5O/c1-9-2-3-15-24-11(8-26-14(19)6-13(25-26)18(20,21)22)5-16(28)27(15)17(9)12-4-10(12)7-23/h2-3,5-6,10,12H,4,8H2,1H3/t10-,12+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

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Article
PubMed
n/an/an/an/a 3.10E+4n/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50206009
PNG
(CHEMBL3983039 | US10280165, Example 35)
Show SMILES Cc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C18H13ClF3N5O/c1-9-2-3-15-24-11(8-26-14(19)6-13(25-26)18(20,21)22)5-16(28)27(15)17(9)12-4-10(12)7-23/h2-3,5-6,10,12H,4,8H2,1H3/t10-,12+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.70E+4n/an/an/an/a



Genentech Inc

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...


ACS Med Chem Lett 8: 84-89 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00388
BindingDB Entry DOI: 10.7270/Q2VX0JH1
More data for this
Ligand-Target Pair