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Found 4 of ic50 for monomerid = 192716
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192716(US11725011, Compound YKL-05-99 | YKL-05-099 (5))
Affinity DataIC50:  40nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192716(US11725011, Compound YKL-05-99 | YKL-05-099 (5))
Affinity DataIC50:  40nMAssay Description:IC50's for selected compounds in Table 5 below were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192716(US11725011, Compound YKL-05-99 | YKL-05-099 (5))
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of SIK2 (unknown origin) assessed as enzyme remaining activity by scanMAX kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192716(US11725011, Compound YKL-05-99 | YKL-05-099 (5))
Affinity DataIC50:  3.44E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In DepthDetails PubMed