BindingDB PrimarySearch

Found 11 of ic50 for monomerid = 99037

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM99037(US8497265, 677)

IC50: 2.60nMAssay Description:Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent

BDBM99037(US8497265, 677)

IC50: 2.90nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid PDB Similars

Details US Patent PDB

3D Structure (crystal)

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM99037(US8497265, 677)

IC50: 3.03E+3nMAssay Description:Inhibition of human PDE2A1 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM99037(US8497265, 677)

IC50: 3.68E+3nMAssay Description:Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM99037(US8497265, 677)

IC50: 5.05E+3nMAssay Description:Inhibition of human PDE4D2 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM99037(US8497265, 677)

IC50: >3.00E+4nMAssay Description:Inhibition of human PDE11A4 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM99037(US8497265, 677)

IC50: >3.00E+4nMAssay Description:Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM99037(US8497265, 677)

IC50: >3.00E+4nMAssay Description:Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM99037(US8497265, 677)

IC50: >3.00E+4nMAssay Description:Inhibition of human PDE5A using FAM-cGMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM99037(US8497265, 677)

IC50: >3.00E+4nMAssay Description:Inhibition of human PDE7A1 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM99037(US8497265, 677)

IC50: >3.00E+4nMAssay Description:Inhibition of human PDE9A2 using FAM-cGMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Filter my 11 hits

Targets 10▿
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 2
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 1
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 1
- cGMP-specific 3',5'-cyclic phosphodiesterase 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 1
Publications 2▿
- Bioorg Med Chem 22: 6570-85 (2015) 10
- US Patent US8497265 (2013) 1
Institutions 2▿
- TBA 10
- Amgen 1
Affinity: 2.6 to 3.0E+4 nM▿
- IC50 11
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0