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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)' and Ligand = 'BDBM340823'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Rattus norvegicus (rat))
BDBM340823
PNG
(US9765040, Compound 15)
Show SMILES CC(C)n1c(nnc1C(C)(C)Oc1c(F)cc(F)cc1F)-c1ccc(cc1F)C(N)=O
Show InChI InChI=1S/C21H20F4N4O2/c1-10(2)29-19(13-6-5-11(18(26)30)7-14(13)23)27-28-20(29)21(3,4)31-17-15(24)8-12(22)9-16(17)25/h5-10H,1-4H3,(H2,26,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...


US Patent US9765040 (2017)

More data for this
Ligand-Target Pair