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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '3-phosphoinositide-dependent protein kinase 1 (51-359)' and Ligand = 'BDBM281808'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281808
PNG
((S)-2-(3-(4-amino-7H-pyrrolo[2,3- d]pyrimidin-5-yl...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1cccc(c1)-c1c[nH]c2ncnc(N)c12)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H23F2N7O/c1-15(17-7-8-21(28)22(29)11-17)36-27(37)19-6-3-9-31-25(19)32-12-16-4-2-5-18(10-16)20-13-33-26-23(20)24(30)34-14-35-26/h2-11,13-15H,12H2,1H3,(H,31,32)(H,36,37)(H3,30,33,34,35)/t15-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair