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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '3-phosphoinositide-dependent protein kinase 1 (51-359)' and Ligand = 'BDBM281816'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281816
PNG
(2-[4-(4-Amino-7-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(cc1)-c1cn(C)c2ncnc(N)c12)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H25F2N7O/c1-16(19-9-10-22(29)23(30)12-19)36-28(38)20-4-3-11-32-26(20)33-13-17-5-7-18(8-6-17)21-14-37(2)27-24(21)25(31)34-15-35-27/h3-12,14-16H,13H2,1-2H3,(H,32,33)(H,36,38)(H2,31,34,35)/t16-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair