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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '3-phosphoinositide-dependent protein kinase 1 (51-359)' and Ligand = 'BDBM281881'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281881
PNG
(3-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]meth...)
Show SMILES C[C@H](NC(=O)c1nccnc1NCc1ccc(s1)-c1ccc2ncnc(N)c2c1)c1cccc(F)c1
Show InChI InChI=1S/C26H22FN7OS/c1-15(16-3-2-4-18(27)11-16)34-26(35)23-25(30-10-9-29-23)31-13-19-6-8-22(36-19)17-5-7-21-20(12-17)24(28)33-14-32-21/h2-12,14-15H,13H2,1H3,(H,30,31)(H,34,35)(H2,28,32,33)/t15-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair