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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '3-phosphoinositide-dependent protein kinase 1 (51-359)' and Ligand = 'BDBM281913'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281913
PNG
(N-cyclopropyl-3-[3-{[(3-{[(5- methylfuran-2-yl)met...)
Show SMILES CC(C)Oc1cc(CNc2ncccc2C(=O)NCc2ccc(C)o2)cc(c1)-c1c[nH]c2ncc(cc12)C(=O)NC1CC1
Show InChI InChI=1S/C33H34N6O4/c1-19(2)42-26-12-21(15-35-30-27(5-4-10-34-30)33(41)38-17-25-9-6-20(3)43-25)11-22(13-26)29-18-37-31-28(29)14-23(16-36-31)32(40)39-24-7-8-24/h4-6,9-14,16,18-19,24H,7-8,15,17H2,1-3H3,(H,34,35)(H,36,37)(H,38,41)(H,39,40)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair