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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM354657'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM354657
PNG
(Cyclohexyl 6-{4-[(4-hydroxyphenyl)(methyl)carbamoy...)
Show SMILES CN(C(=O)c1cc(-c2cc3CCN(Cc3cc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)C(=O)OC2CCCCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C47H57N5O6/c1-32-41(45(54)49(3)37-15-17-39(53)18-16-37)29-44(48(32)2)42-27-34-19-21-51(47(56)58-40-13-5-4-6-14-40)30-36(34)28-43(42)46(55)52-31-35-11-8-7-10-33(35)26-38(52)12-9-20-50-22-24-57-25-23-50/h7-8,10-11,15-18,27-29,38,40,53H,4-6,9,12-14,19-26,30-31H2,1-3H3/t38-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3.10n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9809574 (2017)


Article DOI: 10.1021/jm070125f
BindingDB Entry DOI: 10.7270/Q2MP55DF
More data for this
Ligand-Target Pair