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Found 2 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 5-lipoxygenase' and Ligand = 'BDBM50038460'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50038460
PNG
(CHEMBL3353726)
Show SMILES COc1ccc(cc1)-c1sc(nc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12ClNO2S/c1-20-13-8-4-10(5-9-13)14-15(19)18-16(21-14)11-2-6-12(17)7-3-11/h2-9,19H,1H3
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in human PMNL using arachidonic acid as substrate assessed as product formation incubated for 15 mins prior to substrate addition ...


Eur J Med Chem 89: 503-23 (2014)


Article DOI: 10.1016/j.ejmech.2014.10.054
BindingDB Entry DOI: 10.7270/Q2959K5T
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50038460
PNG
(CHEMBL3353726)
Show SMILES COc1ccc(cc1)-c1sc(nc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12ClNO2S/c1-20-13-8-4-10(5-9-13)14-15(19)18-16(21-14)11-2-6-12(17)7-3-11/h2-9,19H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in human PMNL S100 extract using arachidonic acid as substrate incubated for 15 mins prior to substrate addition measured after 10...


Eur J Med Chem 89: 503-23 (2014)


Article DOI: 10.1016/j.ejmech.2014.10.054
BindingDB Entry DOI: 10.7270/Q2959K5T
More data for this
Ligand-Target Pair